RGD Reference Report - New mutation causing hereditary hepatitis in the laboratory rat. - Rat Genome Database

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New mutation causing hereditary hepatitis in the laboratory rat.

Authors: Yoshida, MC  Masuda, R  Sasaki, M  Takeichi, N  Kobayashi, H  Dempo, K  Mori, M 
Citation: Yoshida MC, etal., J Hered 1987 Nov-Dec;78(6):361-5.
RGD ID: 1302497
Pubmed: PMID:3429843   (View Abstract at PubMed)

A new mutant causing hereditary hepatitis associated with severe jaundice has been discovered in the LEC strain of rats. Hepatitis appears suddenly in adult rats three to four months after birth. The clinical signs of hepatitis are characterized by severe jaundice, subcutaneous bleeding, oliguria, and loss of body weight. The affected rats showed a high lethality and histological changes of the liver with focal necrosis of enlarged hepatocytes without inflammatory cell response. Genetic tests indicate that at least a single autosomal recessive gene is responsible for the major cause of hepatitis. Furthermore, liver cancer appears in long survived rats after recovery from jaundice as well as a few asymptomatic rats without jaundice. The LEC rats thus provide an animal model useful for the basic and clinical studies of hepatitis and liver cancer, including their pathogenesis, prevention, and treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatitis  ISOAtp7b (Rattus norvegicus)1302497; 1302497 RGD 
hepatitis  IAGP 1302497; 1302497; 1302497 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
jaundice  IAGP 1302497; 1302497; 1302497 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Atp7b  (ATPase copper transporting beta)
Atp7bhts  (ATPase copper transporting beta; hepatitis)

Genes (Mus musculus)
Atp7b  (ATPase, Cu++ transporting, beta polypeptide)

Genes (Homo sapiens)
ATP7B  (ATPase copper transporting beta)

LEC/Hok  (Long Evans Cinnamon)

Additional Information