RGD Reference Report - New mutation causing hereditary hepatitis in the laboratory rat. - Rat Genome Database

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New mutation causing hereditary hepatitis in the laboratory rat.

Authors: Yoshida, MC  Masuda, R  Sasaki, M  Takeichi, N  Kobayashi, H  Dempo, K  Mori, M 
Citation: Yoshida MC, etal., J Hered 1987 Nov-Dec;78(6):361-5.
RGD ID: 1302497
Pubmed: PMID:3429843   (View Abstract at PubMed)

A new mutant causing hereditary hepatitis associated with severe jaundice has been discovered in the LEC strain of rats. Hepatitis appears suddenly in adult rats three to four months after birth. The clinical signs of hepatitis are characterized by severe jaundice, subcutaneous bleeding, oliguria, and loss of body weight. The affected rats showed a high lethality and histological changes of the liver with focal necrosis of enlarged hepatocytes without inflammatory cell response. Genetic tests indicate that at least a single autosomal recessive gene is responsible for the major cause of hepatitis. Furthermore, liver cancer appears in long survived rats after recovery from jaundice as well as a few asymptomatic rats without jaundice. The LEC rats thus provide an animal model useful for the basic and clinical studies of hepatitis and liver cancer, including their pathogenesis, prevention, and treatment.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEC/HokRathepatitis  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEC/HokRatjaundice  IAGP  RGD 
Objects Annotated

Strains
LEC/Hok  (Long Evans Cinnamon)

Objects referenced in this article
Gene ATP7B ATPase copper transporting beta Homo sapiens
Gene Atp7b ATPase, copper transporting, beta polypeptide Mus musculus
Gene Atp7b ATPase copper transporting beta Rattus norvegicus
Gene Atp7bhts ATPase copper transporting beta; hepatitis Rattus norvegicus

Additional Information