RGD Reference Report - Possible single dosage effects of the nude gene: suppression of spontaneous development of thymoma and nephropathy in BUF/Mna-rnu/+ rats. - Rat Genome Database

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Possible single dosage effects of the nude gene: suppression of spontaneous development of thymoma and nephropathy in BUF/Mna-rnu/+ rats.

Authors: Matsuyama, M  Yamada, C  Kojima, A 
Citation: Matsuyama M, etal., Jpn J Cancer Res 1987 Jan;78(1):40-4.
RGD ID: 1302469
Pubmed: PMID:3102437   (View Abstract at PubMed)

Single dosage effects of the rat nude gene (rnu) on spontaneous development of epithelial thymoma, muscle atrophy and nephrotic syndrome were studied by comparing littermates of rnu /+ and +/+ rats on a high thymoma strain, BUF/Mna, background. Heterozygous rnu/+ rats had a significantly smaller thymus than the +/+ littermates at 6 weeks of age. The incidence of thymoma at 12 months of age was extremely low in the female rnu/+ rats (3%) as compared with that of the +/+ rats (94%). Development of the nephrotic syndrome but not of the muscle atrophy was also suppressed in the heterozygotes. The results suggest that a recessive mutant gene, rnu, in a single dosage, interfered with critical steps of the disease processes of the thymoma and nephrotic syndrome in BUF/Mna-background rats.



Objects referenced in this article
Strain BUF.Cg-Foxn1rnu/Mna null Rattus norvegicus

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