RGD Reference Report - Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: Comparison with spontaneously hypertensive rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: Comparison with spontaneously hypertensive rats.

Authors: Siegel, AK  Kossmehl, P  Planert, M  Schulz, A  Wehland, M  Stoll, M  Bruijn, JA  De Heer, E  Kreutz, R 
Citation: Siegel AK, etal., Physiol Genomics 2004 Jul 8;18(2):218-25. Epub 2004 May 25.
RGD ID: 1300043
Pubmed: PMID:15161966   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00068.2004   (Journal Full-text)

Our aim was to study the effects of high-salt diet on the genetics of albuminuria and renal injury in the Dahl salt-sensitive (SS) rat. We compared SS with salt-resistant spontaneously hypertensive rats (SHR) and with genetically related salt-sensitive stroke-prone SHR (SHRSP). Moreover, we performed genome-wide linkage analysis to identify quantitative trait loci (QTL) contributing to salt-induced renal injury in an F2-population derived from SS and SHR (n=230). In response to high-salt diet SS and SHRSP developed a striking increase in systolic blood pressure, urinary albumin excretion (UAE), and renal damage indices compared to SHR. Both SHRSP and SS developed severe glomerulosclerosis, while microangiopathy, tubulointerstitial fibrosis and inflammation were more pronounced in SHRSP. We detected two QTL with significant linkage to UAE on rat chromosomes (RNO) 6 and 19. Comparison with the recently identified salt-independent UAE QTL in young animals revealed that the UAE QTL on RNO6 is unique to high-salt conditions, while RNO19 plays a significant role during both low- and high-salt conditions. Some F2-animals demonstrated severe microangiopathy and tubulointerstitial injury, that exceeded the degree observed in the parental SS strain. Three loci demonstrated suggestive linkage to these phenotypes on RNO3, RNO5, and RNO20, while no linkage to glomerular damage was found. Further analyses at these loci indicated, that the severity of renal injury was attributable to the SHR-allele. Our data suggest, that the SHR genetic background confers greater susceptibility for the development of microangiopathy and tubulointerstitial injury in salt-sensitive hypertension than the SS background.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Uae28RatAlbuminuria  IAGP  RGD 
Uae29RatAlbuminuria  IAGP  RGD 
Uae28Ratproteinuria  IAGP  RGD 
Uae29Ratproteinuria  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Uae28Ratalbuminuria  IAGP  RGD 
Uae28Ratincreased urine protein level  IDA  RGD 
Uae29Ratincreased urine protein level  IAGP  RGD 
Objects Annotated

QTLs
Uae28  (Urinary albumin excretion QTL 28)
Uae29  (Urinary albumin excretion QTL 29)

Strains
SHR/FubRkb  (NA)
SS/JrRkb  (NA)


Additional Information