RGD Reference Report - Rat model of familial combined hyperlipidemia as a result of comparative mapping. - Rat Genome Database

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Rat model of familial combined hyperlipidemia as a result of comparative mapping.

Authors: Ueno, T  Tremblay, J  Kunes, J  Zicha, J  Dobesova, Z  Pausova, Z  Deng, AY  Sun, YL  Jacob, HJ  Hamet, P 
Citation: Ueno T, etal., Physiol Genomics 2004 Mar 12;17(1):38-47. Epub 2004 Jan 6.
RGD ID: 1299960
Pubmed: PMID:14709677   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00043.2003   (Journal Full-text)

Total genome scan was carried out in 266 F2 intercrosses from the Prague hypertriglyceridemic (HTG) rat that shares several clinical characteristics with human metabolic syndrome. Two loci for plasma triglycerides (TG) were localized on chromosome 2 (Chr 2) (LOD 4.4, 3.2). The first locus overlapped with the rat syntenic region of the human locus for the metabolic syndrome and for small, dense LDL, while the second overlapped with the syntenic region of another locus for small, dense LDL in humans by the comparative mapping approach. Loci for TG on rat Chr 13 (LOD 3.3) and Chr 1 (LOD 2.7) overlapped with the syntenic region of loci for human familial combined hyperlipidemia (FCHL) in Finnish and Dutch populations, respectively. The concordances of loci for TG localized in this study with previously reported loci for FCHL and its related phenotypes are underlying the generalized importance of these loci in dyslipidemia. These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants.

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Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased circulating cholesterol level  IAGP 1299960compared to LEW femalesRGD 
decreased circulating cholesterol level  QTM 1299960; 1299960 RGD 
decreased circulating triglyceride level sexual_dimorphism IAGP 1299960compared to LEW femalesRGD 
decreased systemic arterial diastolic blood pressure sexual_dimorphism IAGP 1299960compared to LEW femalesRGD 
decreased systemic arterial systolic blood pressure sexual_dimorphism IAGP 1299960compared to LEW femalesRGD 
increased body weight  IDA 1299960; 1299960; 1299960 RGD 
increased body weight  IAGP 1299960 RGD 
increased body weight sexual_dimorphism IAGP 1299960compared to HTG females and LEW femalesRGD 
increased body weight sexual_dimorphism IAGP 1299960compared to LEW femalesRGD 
increased circulating cholesterol level sexual_dimorphism IAGP 1299960compared to LEW femalesRGD 
increased circulating cholesterol level  QTM 1299960; 1299960 RGD 
increased circulating cholesterol level  IDA 1299960; 1299960; 1299960; 1299960 RGD 
increased circulating triglyceride level  IAGP 1299960compared to LEWRGD 
increased circulating triglyceride level  QTM 1299960; 1299960; 1299960; 1299960 RGD 
increased circulating triglyceride level  IDA 1299960; 1299960 RGD 
increased systemic arterial diastolic blood pressure sexual_dimorphismIAGP 1299960compared to HTG females and LEW malesRGD 
increased systemic arterial systolic blood pressure  IAGP 1299960compared to LEWRGD 

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Objects Annotated

QTLs
Bw112  (Body weight QTL 112)
Bw113  (Body weight QTL 113)
Bw114  (Body weight QTL 114)
Bw16  (Body weight QTL 16)
Scl19  (Serum cholesterol QTL 19)
Scl20  (Serum cholesterol level QTL 20)
Scl21  (Serum cholesterol level QTL 21)
Scl33  (Serum cholesterol QTL 33)
Scl34  (Serum cholesterol QTL 34)
Scl35  (Serum cholesterol QTL 35)
Scl36  (Serum cholesterol QTL 36)
Stl25  (Serum triglyceride level QTL 25)
Stl26  (Serum triglyceride level QTL 26)
Stl27  (Serum triglyceride level QTL 27)
Stl28  (Serum triglyceride level QTL 28)
Stl29  (Serum triglyceride level QTL 29)
Stl30  (Serum triglyceride level QTL 30)

Strains
HTG  (Prague hypertriglyceridemic)
LEW  (Lewis)


Additional Information