RGD Reference Report - Prostatic steroid binding protein: organisation of C1 and C2 genes. - Rat Genome Database

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Prostatic steroid binding protein: organisation of C1 and C2 genes.

Authors: Parker, M  Needham, M  White, R  Hurst, H  Page, M 
Citation: Parker M, etal., Nucleic Acids Res 1982 Sep 11;10(17):5121-32.
RGD ID: 1299460
Pubmed: PMID:6292830   (View Abstract at PubMed)
PMCID: PMC320859   (View Article at PubMed Central)

Prostatic steroid binding protein, whose expression is stimulated by androgens, consists of two subunits: one containing the polypeptides C1 and C3 and the other containing C2 and C3. We have characterised genomic clones containing the C1 and C2 genes by restriction enzyme analysis and DNA sequencing. Both genes are 3.2 Kb, have similar exon/intron arrangements and share considerable DNA sequence homologies in their coding regions, intervening sequences and 5' upstream DNA sequence which suggests that they have probably arisen from the duplication of an ancestral gene. The 5' termini of C1 and C2 mRNA have been mapped; the sequence TATAAA appears 30 nucleotides upstream but a CAAT-like sequence at -60 - -80 is absent. Finally, homologous human genes have not been detected.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Scgb1d4Ratextracellular region  TAS  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Scgb1d4Ratsteroid binding  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Scgb1d4  (secretoglobin family 1D member 4)

Objects referenced in this article
Gene Scgb1d2 secretoglobin, family 1D, member 2 Rattus norvegicus

Additional Information