RGD Reference Report - The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. - Rat Genome Database

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

Authors: De Lecea, L  Kilduff, TS  Peyron, C  Gao, X  Foye, PE  Danielson, PE  Fukuhara, C  Battenberg, EL  Gautvik, VT  Bartlett FS, 2ND  Frankel, WN  Van den Pol, AN  Bloom, FE  Gautvik, KM  Sutcliffe, JG 
Citation: de Lecea L, etal., Proc Natl Acad Sci U S A 1998 Jan 6;95(1):322-7.
RGD ID: 1298943
Pubmed: PMID:9419374   (View Abstract at PubMed)
PMCID: PMC18213   (View Article at PubMed Central)

We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin. The hypocretin (Hcrt) protein products are restricted to neuronal cell bodies of the dorsal and lateral hypothalamic areas. The fibers of these neurons are widespread throughout the posterior hypothalamus and project to multiple targets in other areas, including brainstem and thalamus. Hcrt immunoreactivity is associated with large granular vesicles at synapses. One of the Hcrt peptides was excitatory when applied to cultured, synaptically coupled hypothalamic neurons, but not hippocampal neurons. These observations suggest that the hypocretins function within the CNS as neurotransmitters.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HcrtRatneuronal dense core vesicle lumen is_active_inIDA PMID:9419374SynGO 
HcrtRatsecretory granule  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hcrt  (hypocretin neuropeptide precursor)

Objects referenced in this article
Gene HCRT hypocretin neuropeptide precursor Homo sapiens
Gene Brca1 breast cancer 1, early onset Mus musculus
Gene Hcrt hypocretin Mus musculus
Gene Tubg1 tubulin, gamma 1 Mus musculus

Additional Information