RGD Reference Report - Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder. - Rat Genome Database

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Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder.

Authors: Watanabe, Kentaro  Fujii, Hideki  Goto, Shunsuke  Nakai, Kentaro  Kono, Keiji  Watanabe, Shuhei  Shinohara, Masami  Nishi, Shinichi 
Citation: Watanabe K, etal., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170.
RGD ID: 12914778
Pubmed: (View Article at PubMed) PMID:28674323
DOI: Full-text: DOI:10.5551/jat.40170


AIM: Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with all-cause and cardiovascular morbidity and mortality in patients with CKD. Thus, elucidating its pathophysiological mechanisms is essential for improving the prognosis. We evaluated characteristics of CKD-MBD in a newly developed CKD rat model.
METHODS: We used male Sprague-Dawley (SD) rats and spontaneously diabetic Torii (SDT) rats, which are used as models for nonobese type 2 diabetes. CKD was induced by 5/6 nephrectomy (Nx). At 10 weeks, the rats were classified into six groups and administered with a vehicle or a low- or high-dose paricalcitol thrice a week. At 20 weeks, the rats were sacrificed; blood and urinary biochemical analyses and histological analysis of the aorta were performed.
RESULTS: At 20 weeks, hemoglobin A1c (HbA1c) levels, blood pressure, and renal function were not significantly different among the six groups. Serum calcium and phosphate levels tended to be higher in SDT-Nx rats than in SD-Nx rats. The urinary excretion of calcium and phosphate was significantly greater in SDT-Nx rats than in SD-Nx rats. After administering paricalcitol, serum parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) levels were significantly higher in SDT-Nx rats than in SD-Nx rats. The degree of aortic calcification was significantly more severe and the aortic calcium content was significantly greater in SDT-Nx rats than in SD-Nx rats.
CONCLUSIONS: We suggest that our new CKD rat model using SDT rats represents a useful CKD-MBD model, and this model was greatly influenced by paricalcitol administration. Further studies are needed to clarify the detailed mechanisms underlying this model.



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Strains
SD  (Sprague-Dawley)
SDT/Jcl  (NA)


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