RGD Reference Report - Effect of ageing on healing of bilateral mandibular condyle fractures in a rat model. - Rat Genome Database

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Effect of ageing on healing of bilateral mandibular condyle fractures in a rat model.

Authors: Tatsumi, H  Hideshima, K  Kanno, T  Hashimoto, R  Matsumoto, A  Otani, H  Sekine, J 
Citation: Tatsumi H, etal., Int J Oral Maxillofac Surg. 2014 Feb;43(2):185-93. doi: 10.1016/j.ijom.2013.07.742. Epub 2013 Aug 28.
RGD ID: 12911207
Pubmed: PMID:23992905   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ijom.2013.07.742   (Journal Full-text)

To examine the hypothesis that conservative treatment is applicable to younger patients with bilateral mandibular condylar fractures, we studied the effect of ageing on the healing of bilateral mandibular condylar fractures in a rat model. Male Sprague-Dawley rats aged 3, 6, and 36 weeks (n=25/cohort, total n=75) were divided into a fracture group (n=12) and a sham control group (n=12); one rat from each cohort was used as a normal unoperated control. Cell proliferation was evaluated using the bromodeoxyuridine (BrdU) labelling index (LI). Osteochondrogenesis was assessed by the expression of Indian hedgehog (Ihh), type X collagen, and osteocalcin in the condylar head. Condylar fracture healing was found to be delayed by ageing. BrdU LI values in the fracture groups were higher in younger rats than in older rats at 8 weeks after fracture. The number of Ihh-positive cells in the fracture groups increased significantly up to 2 weeks after fracture, and then gradually decreased until 8 weeks after fracture. The findings of this study support the clinical concept of conservative treatment of bilateral condylar fractures in younger patients, but functional issues regarding ramus height and its consequences on occlusion have not been tested in this study.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IHHHumanMandibular Fractures  ISOIhh (Rattus norvegicus) RGD 
IhhRatMandibular Fractures  IEP  RGD 
IhhMouseMandibular Fractures  ISOIhh (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ihh  (Indian hedgehog signaling molecule)

Genes (Mus musculus)
Ihh  (Indian hedgehog)

Genes (Homo sapiens)
IHH  (Indian hedgehog signaling molecule)


Additional Information