RGD Reference Report - Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent Cryptosporidium infections in young children. - Rat Genome Database

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Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent Cryptosporidium infections in young children.

Authors: Carmolli, Marya  Duggal, Priya  Haque, Rashidul  Lindow, Janet  Mondal, Dinesh  Petri, William A  Mourningstar, Phoenix  Larsson, Catherine J  Sreenivasan, Meera  Khan, Salwa  Kirkpatrick, B D 
Citation: Carmolli M, etal., J Infect Dis. 2009 Nov 15;200(10):1540-7. doi: 10.1086/606013.
RGD ID: 12910843
Pubmed: PMID:19827946   (View Abstract at PubMed)
PMCID: PMC3400050   (View Article at PubMed Central)
DOI: DOI:10.1086/606013   (Journal Full-text)

Mannose-binding lectin (MBL) is an evolutionarily conserved protein that functions in human innate immunity by binding to microbial surfaces and promoting opsonophagocytosis. MBL has been shown to bind to Cryptosporidium sporozoites, and earlier work has suggested that the protective role of MBL may be most important in childhood. We evaluated the association between polymorphisms in the MBL gene (MBL2), serum MBL deficiency, and infection with Cryptosporidium, Entamoeba histolytica, and Giardia intestinalis in children. A large, prospective cohort of Bangladeshi preschool children was followed up for >3 years. Clinical outcomes, serum MBL levels, and MBL2 polymorphisms and haplotypes were determined. Statistically significant associations with E. histolytica and G. intestinalis were not found. Serum MBL deficiency, polymorphisms in the -221 promoter region, and the YO/XA MBL2 haplotype were strongly associated with Cryptosporidium infections, particularly recurrent infection. Children with multiple infections with Cryptosporidium were more likely to be MBL deficient (odds ratio [OR], 10.45), carry the -221 promoter variant (OR, 4.02), and have the YO/XA haplotype (OR, 4.91). We have identified a potentially important component of the human innate immune response to Cryptosporidum infection. Further work is needed to evaluate the mechanism of protection of MBL in Cryptosporidium infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MBL2Humancryptosporidiosis susceptibilityIAGP DNA:polymorphisms more ...RGD 
Mbl2Ratcryptosporidiosis susceptibilityISOMBL2 (Homo sapiens)DNA:polymorphisms more ...RGD 
Mbl2Mousecryptosporidiosis susceptibilityISOMBL2 (Homo sapiens)DNA:polymorphisms more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information