RGD Reference Report - Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats. - Rat Genome Database

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Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats.

Authors: Thompson, Nichola M  Davies, Jeffrey S  Mode, Agneta  Houston, Pamela A  Wells, Timothy 
Citation: Thompson NM, etal., Endocrinology. 2003 Nov;144(11):4859-67. Epub 2003 Jul 24.
RGD ID: 12905040
Pubmed: PMID:12960077   (View Abstract at PubMed)
DOI: DOI:10.1210/en.2003-0423   (Journal Full-text)

The peptide hormone ghrelin binds to the GH secretagogue receptor (GHS-R), stimulates GH secretion, and promotes adipogenesis. However, continuous GHS infusion does not stimulate skeletal growth and is associated with desensitization to further GH secretagogue treatment. In this study, 7-d intermittent (i.e. every 3 h) infusion of ghrelin, or the GH secretagogue, GH-releasing peptide-6, in the moderately GH- deficient transgenic growth-retarded rat, augmented GH secretion, leading to a sustained acceleration in skeletal growth. In contrast, continuous infusion of ghrelin, or GH-releasing peptide-6, suppressed the amplitude of spontaneous GH secretory episodes and produced only a transient increase in body weight gain. The reduction in GH secretion seen with continuous GHS-R activation was not associated with a desensitization of the pituitary to GH-releasing factor or to down-regulation of hypothalamic GHS-R mRNA expression. Continuous ghrelin treatment elicited an increase in somatostatin mRNA expression in the periventricular nuclei. Thus, exposure to continuously elevated circulating ghrelin may be responsible for the suppression of GH secretion reported in rats after prolonged starvation.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GhrlRatpositive regulation of bone development  IDA  RGD 
GhrlRatpositive regulation of growth  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghrl  (ghrelin and obestatin prepropeptide)


Additional Information