RGD Reference Report - The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis. - Rat Genome Database

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The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis.

Authors: Bueno, Márcia Pereira  Gonçalves, Frances Lilian Lanhellas  Guadagnini, Dioze  Barini, Ricardo  Saad, Mario José Abdalla  Gallindo, Rodrigo Melo  Schmidt, Augusto Frederico  Sbragia, Lourenço 
Citation: Bueno MP, etal., Acta Cir Bras. 2013;28 Suppl 1:3-7.
RGD ID: 12904922
Pubmed: PMID:23381816   (View Abstract at PubMed)


PURPOSE: To evaluate the intrauterine growth restriction (IUGR) by the expression of IR-ß, IRS-1, IRS-2, IGF-IRß and Ikappaß in experimental model of gastroschisis.
METHODS: Pregnant rats at 18.5 days of gestation were submitted to surgery to create experimental fetal gastroschisis (term = 22 days) were divided in three groups: gastroschisis (G), control (C) and sham (S). Fetuses were evaluated for body weight (BW), intestinal (IW), liver (LW) and their relations IW/BW and LW/BW. IR-ß and IGF-IRß receptors, IRS-1 and IRS-2 substrates and Ikappaß protein were analyzed by western blotting.
RESULTS: BW was lower in G, the IW and IW / BW were greater than C and S (p<0.05) groups. The liver showed no differences between groups. In fetuses with gastroschisis, compared with control fetuses, the expression of IGF-IRß (p<0.001) and Ikappaß (p<0.001) increased in the liver and intestine, as well as IR-ß (p<0.001) which decreased in both. In contrast to the intestine, IRS-1 (p<0.001) increased in the liver and IRS-2 decreased (p<0.01).
CONCLUSION: The axis of the intestine liver has an important role in inflammation, with consequent changes in the metabolic pathway of glucose can contribute to the IUGR in fetuses with gastroschisis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IGF1RHumangastroschisis  ISOIgf1r (Rattus norvegicus)protein:increased expression:liver and intestine (rat)RGD 
Igf1rRatgastroschisis  IEP protein:increased expression:liver and intestine (rat)RGD 
Igf1rMousegastroschisis  ISOIgf1r (Rattus norvegicus)protein:increased expression:liver and intestine (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1r  (insulin-like growth factor 1 receptor)

Genes (Mus musculus)
Igf1r  (insulin-like growth factor I receptor)

Genes (Homo sapiens)
IGF1R  (insulin like growth factor 1 receptor)


Additional Information