RGD Reference Report - [rdw rats, a new hereditary dwarf model in the rat]. - Rat Genome Database

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[rdw rats, a new hereditary dwarf model in the rat].

Authors: Koto, M  Sato, T  Okamoto, M  Adachi, J 
Citation: Koto M, etal., Jikken Dobutsu. 1988 Jan;37(1):21-30.
RGD ID: 12880373
Pubmed: PMID:3366187   (View Abstract at PubMed)

A new hereditary dwarf mutation was found in Csk: Wistar-Imamichi rat breeding colony. The mutant rats and control normal rats were studied with clinical, genetical and histological examination. The result showed that the present mutation was inherited in autosomal recessive trait (gene symbol; rdw) and was provoked with the hypoplasia of pars distalis (anterior pituitary), in particular the secretory cells of GH, PRL and TSH. The characteristics of the present mutant (rdw) was very similar to dw mouse, and was usefull for endocrinological research as an animal model of human pituitary dwarfism.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TgRatsmall adenohypophysis  IAGP  RGD 
TgrdwRatsmall adenohypophysis  IAGP  RGD 
WIC-Tgrdw/KtsRatsmall adenohypophysis  IAGP  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Tg  (thyroglobulin)
Tgrdw  (thyroglobulin; rdw mutant)

Genes (Mus musculus)
Tg  (thyroglobulin)

Genes (Homo sapiens)
TG  (thyroglobulin)

Strains
WIC-Tgrdw/Kts  (NA)


Additional Information