RGD Reference Report - Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat.

Advanced Search (OLGA)

General

Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat.
Authors:	Gheni, Ghupurjan Yokoi, Norihide Beppu, Masayuki Yamaguchi, Takuro Hidaka, Shihomi Kawabata, Ayako Hoshino, Yoshikazu Hoshino, Masayuki Seino, Susumu
Citation:	Gheni G, etal., J Diabetes Res. 2015;2015:261418. doi: 10.1155/2015/261418. Epub 2015 Apr 16.
RGD ID:	12859275
Pubmed:	PMID:25961052 (View Abstract at PubMed)
PMCID:	PMC4415487 (View Article at PubMed Central)
DOI:	DOI:10.1155/2015/261418 (Journal Full-text)
We recently established a novel animal model of obese type 2 diabetes (T2D), the Zucker fatty diabetes mellitus (ZFDM) rat strain harboring the fatty mutation (fa) in the leptin receptor gene. Here we performed a phenotypic characterization of the strain, focusing mainly on the prediabetic state. At 6-8 weeks of age, fa/fa male rats exhibited mild glucose intolerance and severe insulin resistance. Although basal insulin secretion was remarkably high in the isolated pancreatic islets, the responses to both glucose stimulation and the incretin GLP-1 were retained. At 10-12 weeks of age, fa/fa male rats exhibited marked glucose intolerance as well as severe insulin resistance similar to that at the earlier age. In the pancreatic islets, the insulin secretory response to glucose stimulation was maintained but the response to the incretin was diminished. In nondiabetic Zucker fatty (ZF) rats, the insulin secretory responses to both glucose stimulation and the incretin in the pancreatic islets were similar to those of ZFDM rats. As islet architecture was destroyed with age in ZFDM rats, a combination of severe insulin resistance, diminished insulin secretory response to incretin, and intrinsic fragility of the islets may cause the development of T2D in this strain.

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Ho:ZFDM-Lepr^fa	Rat	Insulin Resistance		IAGP		compared to fa/+ heterozygotes	RGD
Slc:ZUC-Lepr^fa-/-	Rat	Insulin Resistance		IAGP		compared to wt homozygotes	RGD

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Ho:ZFDM-Lepr^fa	Rat	impaired glucose tolerance		IAGP			RGD
Slc:ZUC-Lepr^fa-/-	Rat	impaired glucose tolerance		IAGP			RGD
Ho:ZFDM-Lepr^fa	Rat	insulin resistance		IAGP			RGD
Slc:ZUC-Lepr^fa-/-	Rat	insulin resistance		IAGP			RGD

Objects Annotated

Strains

Ho:ZFDM-Lepr^fa (Zucker Fatty Diabetes Mellitus rats)

Slc:ZUC-Lepr^fa-/- (Zucker fatty rats)

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat.

Mammalian Phenotype