RGD Reference Report - Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. - Rat Genome Database

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Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.

Authors: Chen, Wen G  Chang, Qiang  Lin, Yingxi  Meissner, Alexander  West, Anne E  Griffith, Eric C  Jaenisch, Rudolf  Greenberg, Michael E 
Citation: Chen WG, etal., Science. 2003 Oct 31;302(5646):885-9.
RGD ID: 12790707
Pubmed: PMID:14593183   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1086446   (Journal Full-text)

Mutations in MeCP2, which encodes a protein that has been proposed to function as a global transcriptional repressor, are the cause of Rett syndrome (RT T), an X-linked progressive neurological disorder. Although the selective inactivation of MeCP2 in neurons is sufficient to confer a Rett-like phenotype in mice, the specific functions of MeCP2 in postmitotic neurons are not known. We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene. Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription. These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Mecp2Ratcellular response to potassium ion  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mecp2  (methyl CpG binding protein 2)


Additional Information