RGD Reference Report - Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. - Rat Genome Database

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Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells.

Authors: van der Vlugt, LuciĆ«n E P M  Labuda, Lucja A  Ozir-Fazalalikhan, Arifa  Lievers, Ellen  Gloudemans, Anouk K  Liu, Kit-Yeng  Barr, Tom A  Sparwasser, Tim  Boon, Louis  Ngoa, Ulysse Ateba  Feugap, Eliane Ngoune  Adegnika, Ayola A  Kremsner, Peter G  Gray, David  Yazdanbakhsh, Maria  Smits, Hermelijn H 
Citation: van der Vlugt LE, etal., PLoS One. 2012;7(2):e30883. doi: 10.1371/journal.pone.0030883. Epub 2012 Feb 8.
RGD ID: 127345101
Pubmed: PMID:22347409   (View Abstract at PubMed)
PMCID: PMC3275567   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0030883   (Journal Full-text)

Chronic helminth infections, such as schistosomes, are negatively associated with allergic disorders. Here, using B cell IL-10-deficient mice, Schistosoma mansoni-mediated protection against experimental ovalbumin-induced allergic airway inflammation (AAI) was shown to be specifically dependent on IL-10-producing B cells. To study the organs involved, we transferred B cells from lungs, mesenteric lymph nodes or spleen of OVA-infected mice to recipient OVA-sensitized mice, and showed that both lung and splenic B cells reduced AAI, but only splenic B cells in an IL-10-dependent manner. Although splenic B cell protection was accompanied by elevated levels of pulmonary FoxP3(+) regulatory T cells, in vivo ablation of FoxP3(+) T cells only moderately restored AAI, indicating an important role for the direct suppressory effect of regulatory B cells. Splenic marginal zone CD1d(+) B cells proved to be the responsible splenic B cell subset as they produced high levels of IL-10 and induced FoxP3(+) T cells in vitro. Indeed, transfer of CD1d(+) MZ-depleted splenic B cells from infected mice restored AAI. Markedly, we found a similarly elevated population of CD1d(hi) B cells in peripheral blood of Schistosoma haematobium-infected Gabonese children compared to uninfected children and these cells produced elevated levels of IL-10. Importantly, the number of IL-10-producing CD1d(hi) B cells was reduced after anti-schistosome treatment. This study points out that in both mice and men schistosomes have the capacity to drive the development of IL-10-producing regulatory CD1d(hi) B cells and furthermore, these are instrumental in reducing experimental allergic inflammation in mice.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD1DHumanurinary schistosomiasis  IEP protein:increased expression:B cell (human)RGD 
Cd1d1Raturinary schistosomiasis  ISOCD1D (Homo sapiens)protein:increased expression:B cell (human)RGD 
Cd1d1Mouseurinary schistosomiasis  ISOCD1D (Homo sapiens)protein:increased expression:B cell (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd1d1  (CD1d1 molecule)

Genes (Mus musculus)
Cd1d1  (CD1d1 antigen)

Genes (Homo sapiens)
CD1D  (CD1d molecule)


Additional Information