RGD Reference Report - The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage. - Rat Genome Database

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The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage.

Authors: Liu, E  Peng, Xianlong  Ma, Haowen  Zhang, Yan  Yang, Xiaomei  Zhang, Yixuan  Sun, Linlin  Yan, Junhao 
Citation: Liu E, etal., Front Aging Neurosci. 2021 Jan 26;12:611494. doi: 10.3389/fnagi.2020.611494. eCollection 2020.
RGD ID: 127284879
Pubmed: PMID:33574749   (View Abstract at PubMed)
PMCID: PMC7870692   (View Article at PubMed Central)
DOI: DOI:10.3389/fnagi.2020.611494   (Journal Full-text)

The mechanism of brain injury following subarachnoid hemorrhage (SAH) has not yet been clarified. The glymphatic system (GS), a glia-dependent waste clearance pathway, drains away soluble waste proteins and metabolic products, even some toxic factors from the brain. Aquaporin-4 (Aqp4) is highly expressed on the astrocyte foot processes and facilitates the interstitial fluid (ISF) transportation in the GS system. In this study, the role of Aqp4 in the GS injury after SAH was explored using Aqp4 gene knockout (Aqp4-/-) Sprague Dawley rats. The results of MRI, fluorescent imaging, and transmission electron microscopy (TEM) indicated that, after SAH, the inflow of cerebrospinal fluid (CSF) into the brain and the clearance of ISF from the brain were both significantly decreased. Meanwhile, the expression level of Aqp4 around the artery was markedly higher than that around the vein following SAH. Aqp4 knockout exacerbated the GS damage after SAH. In summary, after SAH, there was an apparent GS impairment, and Aqp4 played key roles in modulating the function of GS in the brain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Subarachnoid Hemorrhage exacerbatesISOAqp4 (Rattus norvegicus)127284879; 127284879 RGD 
Subarachnoid Hemorrhage  ISOAqp4 (Rattus norvegicus)127284879; 127284879mRNA:increased expression:brain:RGD 
Subarachnoid Hemorrhage exacerbatesIMP 127284879; 127284879; 127284879 RGD 
Subarachnoid Hemorrhage  IEP 127284879mRNA:increased expression:brain:RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal glymphatic system physiology  IMP 127284879; 127284879; 127284879 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Aqp4  (aquaporin 4)
Aqp4em1Hrt  (aquaporin 4; TALEN induced mutant 1, Hrt)

Genes (Mus musculus)
Aqp4  (aquaporin 4)

Genes (Homo sapiens)
AQP4  (aquaporin 4)

SD-Aqp4em1Hrt  (NA)

Additional Information