RGD Reference Report - Tissue remodeling in the acute otitis media mouse model. - Rat Genome Database

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Tissue remodeling in the acute otitis media mouse model.

Authors: Sautter, Nathan B  Delaney, Katherine L  Hausman, Frances A  Trune, Dennis R 
Citation: Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
RGD ID: 127284853
Pubmed: PMID:21889218   (View Abstract at PubMed)
PMCID: PMC3197788   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ijporl.2011.07.026   (Journal Full-text)


OBJECTIVES: Otitis media is an infectious, inflammatory process involving the middle ear space. Chronic inflammation is associated with fibrosis, scarring and osteogenesis within the middle ear, which may contribute to subsequent hearing loss and increase the difficulty of treatment.
METHODS: Heat-killed Streptococcus pneumoniae was injected into the middle ears of 8-12 week old Balb/c mice. Control mice were treated with PBS middle ear injections. Middle ears were harvested at 1, 3, 5 and 7 days following injection (n=8 for each time point). The middle ears were processed using standard RT-PCR techniques. Up- and down-regulation of mRNA expression of various members of the Bone Morphogenetic Protein (BMP), Fibroblast Growth Factor (FGF) and Matrix Metalloproteinase (MMP) families was quantified and compared to PBS treated controls (n=8 for each time point).
RESULTS: Significant upregulation of MMP2, MMP3 and MMP9 was observed at varying time points (p<0.05). Significant downregulation of BMP3, BMP4, BMP5 BMP6 and BMP8a was seen at varying time points (p<0.05). Significant downregulation of FGF3, FGF6, FGF10 and FGFr1 was observed at varying time points (p<0.05). No significant expression of BMP8b, BMP9, BMP10, FGF5, FGF8, MMP1a, MMP7 and MMP14 was detected within the middle ear.
CONCLUSIONS: Inflammation within the middle ear following injection of bacterial products results in changes in the regulation of several tissue remodeling cytokines and proteinases in the mouse model. Further understanding of these molecular processes may allow for the development of treatment modalities aimed at preventing middle ear tissue remodeling.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BMP1HumanAcute Otitis Media  ISOBmp1 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
BMP4HumanAcute Otitis Media  ISOBmp4 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
BMP6HumanAcute Otitis Media  ISOBmp6 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
BMP7HumanAcute Otitis Media  ISOBmp7 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
BMP8AHumanAcute Otitis Media  ISOBmp8a (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Bmp1RatAcute Otitis Media  ISOBmp1 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
Bmp1MouseAcute Otitis Media  IEP mRNA:increased expression:middle ear (mouse)RGD 
Bmp4RatAcute Otitis Media  ISOBmp4 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Bmp4MouseAcute Otitis Media  IEP mRNA:decreased expression:middle ear (mouse)RGD 
Bmp6RatAcute Otitis Media  ISOBmp6 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Bmp6MouseAcute Otitis Media  IEP mRNA:decreased expression:middle ear (mouse)RGD 
Bmp7RatAcute Otitis Media  ISOBmp7 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
Bmp7MouseAcute Otitis Media  IEP mRNA:increased expression:middle ear (mouse)RGD 
Bmp8aRatAcute Otitis Media  ISOBmp8a (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Bmp8aMouseAcute Otitis Media  IEP mRNA:decreased expression:middle ear (mouse)RGD 
FGF10HumanAcute Otitis Media  ISOFgf10 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
FGF3HumanAcute Otitis Media  ISOFgf3 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
FGF6HumanAcute Otitis Media  ISOFgf6 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
FGFR1HumanAcute Otitis Media  ISOFgfr1 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Fgf10RatAcute Otitis Media  ISOFgf10 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Fgf10MouseAcute Otitis Media  IEP mRNA:decreased expression:middle ear (mouse)RGD 
Fgf3RatAcute Otitis Media  ISOFgf3 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Fgf3MouseAcute Otitis Media  IEP mRNA:decreased expression:middle ear (mouse)RGD 
Fgf6RatAcute Otitis Media  ISOFgf6 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Fgf6MouseAcute Otitis Media  IEP mRNA:decreased expression:middle ear (mouse)RGD 
Fgfr1RatAcute Otitis Media  ISOFgfr1 (Mus musculus)mRNA:decreased expression:middle ear (mouse)RGD 
Fgfr1MouseAcute Otitis Media  IEP mRNA:decreased expression:middle ear (mouse)RGD 
MMP2HumanAcute Otitis Media  ISOMmp2 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
MMP3HumanAcute Otitis Media  ISOMmp3 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
MMP9HumanAcute Otitis Media  ISOMmp9 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
Mmp2RatAcute Otitis Media  ISOMmp2 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
Mmp2MouseAcute Otitis Media  IEP mRNA:increased expression:middle ear (mouse)RGD 
Mmp3RatAcute Otitis Media  ISOMmp3 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
Mmp3MouseAcute Otitis Media  IEP mRNA:increased expression:middle ear (mouse)RGD 
Mmp9RatAcute Otitis Media  ISOMmp9 (Mus musculus)mRNA:increased expression:middle ear (mouse)RGD 
Mmp9MouseAcute Otitis Media  IEP mRNA:increased expression:middle ear (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp1  (bone morphogenetic protein 1)
Bmp4  (bone morphogenetic protein 4)
Bmp6  (bone morphogenetic protein 6)
Bmp7  (bone morphogenetic protein 7)
Bmp8a  (bone morphogenetic protein 8a)
Fgf10  (fibroblast growth factor 10)
Fgf3  (fibroblast growth factor 3)
Fgf6  (fibroblast growth factor 6)
Fgfr1  (Fibroblast growth factor receptor 1)
Mmp2  (matrix metallopeptidase 2)
Mmp3  (matrix metallopeptidase 3)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Bmp1  (bone morphogenetic protein 1)
Bmp4  (bone morphogenetic protein 4)
Bmp6  (bone morphogenetic protein 6)
Bmp7  (bone morphogenetic protein 7)
Bmp8a  (bone morphogenetic protein 8a)
Fgf10  (fibroblast growth factor 10)
Fgf3  (fibroblast growth factor 3)
Fgf6  (fibroblast growth factor 6)
Fgfr1  (fibroblast growth factor receptor 1)
Mmp2  (matrix metallopeptidase 2)
Mmp3  (matrix metallopeptidase 3)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
BMP1  (bone morphogenetic protein 1)
BMP4  (bone morphogenetic protein 4)
BMP6  (bone morphogenetic protein 6)
BMP7  (bone morphogenetic protein 7)
BMP8A  (bone morphogenetic protein 8a)
FGF10  (fibroblast growth factor 10)
FGF3  (fibroblast growth factor 3)
FGF6  (fibroblast growth factor 6)
FGFR1  (fibroblast growth factor receptor 1)
MMP2  (matrix metallopeptidase 2)
MMP3  (matrix metallopeptidase 3)
MMP9  (matrix metallopeptidase 9)


Additional Information