RGD Reference Report - HLA-DQA1/B1 alleles as putative susceptibility markers in congenital toxoplasmosis. - Rat Genome Database

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HLA-DQA1/B1 alleles as putative susceptibility markers in congenital toxoplasmosis.

Authors: Shimokawa, Paulo Tadashi  Targa, Lília Spaleta  Yamamoto, Lidia  Rodrigues, Jonatas Cristian  Kanunfre, Kelly Aparecida  Okay, Thelma Suely 
Citation: Shimokawa PT, etal., Virulence. 2016 May 18;7(4):456-64. doi: 10.1080/21505594.2016.1150401. Epub 2016 Feb 8.
RGD ID: 126928144
Pubmed: PMID:26856406   (View Abstract at PubMed)
PMCID: PMC4871673   (View Article at PubMed Central)
DOI: DOI:10.1080/21505594.2016.1150401   (Journal Full-text)

Host and parasite genotypes are among the factors associated with congenital toxoplasmosis pathogenesis. As HLA class II molecules play a key role in the immune system regulation, the aim of this study was to investigate whether HLA-DQA1/B1 alleles are associated with susceptibility or protection to congenital toxoplasmosis. One hundred and twenty-two fetuses with and 103 without toxoplasmosis were studied. The two study groups were comparable according to a number of socio-demographic and genetic variables. HLA alleles were typed by PCR-SSP. In the HLA-DQA1 region, the allele frequencies showed that *01:03 and *03:02 alleles could confer susceptibility (OR= 3.06, p = 0.0002 and OR= 9.60, p= 0.0001, respectively) as they were more frequent among infected fetuses. Regarding the HLA-DQB1 region, the *05:04 allele could confer susceptibility (OR = 6.95, p < 0.0001). Of the 122 infected fetuses, 10 presented susceptibility haplotypes contrasting with only one in the non-infected group. This difference was not statistically significant after correction for multiple comparison (OR = 9.37, p=0.011). In the casuistic, there were two severely damaged fetuses with high parasite loads determined in amniotic fluid samples and HLA-DQA1 susceptibility alleles. In the present study, a discriminatory potential of HLA-DQA1/B1 alleles to identify susceptibility to congenital toxoplasmosis and the most severe cases has been shown.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H2-AaMousecongenital toxoplasmosis susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphisms: :HLA-DQA1*01:03 and HLA-DQA1*03:02 (human)RGD 
HLA-DQA1Humancongenital toxoplasmosis susceptibilityIAGP DNA:polymorphisms: :HLA-DQA1*01:03 and HLA-DQA1*03:02 (human)RGD 
RT1-BaRatcongenital toxoplasmosis susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphisms: :HLA-DQA1*01:03 and HLA-DQA1*03:02 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-DQA1HumanSevere toxoplasmosis susceptibilityIAGP DNA:polymorphisms: :HLA-DQA1*01:03 and HLA-DQA1*03:02 RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)


Additional Information