RGD Reference Report - The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma. - Rat Genome Database

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The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma.

Authors: Kobayashi, Shogo  Tomokuni, Akira  Takahashi, Hidenori  Akita, Hirofumi  Sugimura, Keijiro  Miyoshi, Norikatsu  Moon, Jeong Ho  Yasui, Masayoshi  Omori, Takeshi  Ohue, Masayuki  Fujiwara, Yoshiyuki  Yano, Masahiko  Sakon, Masato 
Citation: Kobayashi S, etal., Gastrointest Tumors. 2017 Mar;3(3-4):141-152. doi: 10.1159/000455955. Epub 2017 Feb 8.
RGD ID: 126790579
Pubmed: PMID:28611981   (View Abstract at PubMed)
PMCID: PMC5465674   (View Article at PubMed Central)
DOI: DOI:10.1159/000455955   (Journal Full-text)


BACKGROUND/AIMS: Alpha-fetoprotein (AFP) mRNA-expressing cells are candidates for circulating tumor cells in hepatocellular carcinoma. We analyzed portal vein blood, peripheral blood, and peritoneal lavage samples to detect the presence of AFP mRNA-expressing cells, and explored their relationship with metastasis.
METHODS: We measured the AFP mRNA expression in 112 sets of portal vein and peripheral blood samples and 61 peritoneal lavage samples that had been obtained during surgery. We estimated the change in the positive ratio of patients with AFP mRNA, the associated background factors, and the rate of recurrence.
RESULTS: The change in AFP mRNA positivity in the peripheral blood specimens was remarkable, while that in the portal vein blood and peritoneal lavage samples was similar during hepatectomy. Tumor location was the only factor associated with AFP mRNA positivity. The rate of recurrence was higher in the patients who were positive for AFP mRNA than in those who were negative 9-24 months after hepatectomy. During this limited period, the recurrence rate in the AFP mRNA-positive cases was significantly higher than that in the AFP mRNA-negative cases (p = 0.0472). Postoperative AFP mRNA positivity was not related to very early recurrence (0-9 months) or multicentric liver carcinogenesis (>24 months).
CONCLUSION: AFP mRNA positivity in the peripheral blood was elevated after hepatectomy, and the elevation depended on the tumor location. AFP mRNA positivity might contribute to recurrence-free survival 9-24 months after hepatectomy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AFPHumanhepatocellular carcinoma disease_progressionIEP  RGD 
AfpRathepatocellular carcinoma disease_progressionISOAFP (Homo sapiens) RGD 
AfpMousehepatocellular carcinoma disease_progressionISOAFP (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Afp  (alpha-fetoprotein)

Genes (Mus musculus)
Afp  (alpha fetoprotein)

Genes (Homo sapiens)
AFP  (alpha fetoprotein)


Additional Information