RGD Reference Report - The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. - Rat Genome Database

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The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.

Authors: Hall, Aisling O'Hara  Beiting, Daniel P  Tato, Cristina  John, Beena  Oldenhove, Guillaume  Lombana, Claudia Gonzalez  Pritchard, Gretchen Harms  Silver, Jonathan S  Bouladoux, Nicolas  Stumhofer, Jason S  Harris, Tajie H  Grainger, John  Wojno, Elia D Tait  Wagage, Sagie  Roos, David S  Scott, Philip  Turka, Laurence A  Cherry, Sara  Reiner, Steven L  Cua, Daniel  Belkaid, Yasmine  Elloso, M Merle  Hunter, Christopher A 
Citation: Hall AO, etal.
RGD ID: 126790522
Pubmed: PMID:22981537   (View Abstract at PubMed)
PMCID: PMC3477519   (View Article at PubMed Central)
DOI: DOI:10.1016/j.immuni.2012.06.014   (Journal Full-text)

Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
toxoplasmosis  ISOIl27 (Mus musculus)126790522; 126790522 RGD 
toxoplasmosis  IMP 126790522 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information