RGD Reference Report - Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. - Rat Genome Database

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Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling.

Authors: Liu, Li  Cao, Zhongying  Chen, Jing  Li, Rui  Cao, Yanhua  Zhu, Chengliang  Wu, Kailang  Wu, Jianguo  Liu, Fang  Zhu, Ying 
Citation: Liu L, etal., J Biol Chem. 2012 Apr 6;287(15):11899-910. doi: 10.1074/jbc.M111.308064. Epub 2012 Feb 16.
RGD ID: 126790513
Pubmed: PMID:22343630   (View Abstract at PubMed)
PMCID: PMC3320938   (View Article at PubMed Central)
DOI: DOI:10.1074/jbc.M111.308064   (Journal Full-text)

We previously reported that IL-27, which belongs to the IL-12 family of cytokines, is elevated in the serum of patients infected with influenza A virus (IAV). Here, we show that the expression of IL-27 was significantly up-regulated in A549 human lung epithelial cells and human peripheral blood mononuclear cells infected with IAV. Additionally, IAV triggered IL-27 expression through protein kinase A and cAMP-response element-binding protein signaling, which was mediated by cyclooxygenase-2-derived prostaglandin E(2). IL-27 inhibited IAV replication by STAT1/2/3 phosphorylation and activated antiviral factor protein kinase R phosphorylation. Clinical analysis showed that IL-27 levels were significantly elevated in a cohort of patients infected with IAV compared with healthy individuals and that circulating IL-27 levels were tightly and positively correlated with prostaglandin E(2) levels. These results indicate that IL-27 expression is one host immune factor produced in response to IAV infection and that elevated IL-27 levels inhibit viral replication.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
influenza A  IEP 126790513protein:increased expression:blood serum (human)RGD 
influenza A  ISOIL27 (Homo sapiens)126790513; 126790513protein:increased expression:blood serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information