RGD Reference Report - Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice. - Rat Genome Database

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Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice.

Authors: Fazalul Rahiman, S S  Basir, R  Talib, H  Tie, T H  Chuah, Y K  Jabbarzare, M  Chong, W C  Mohd Yusoff, M A  Nordin, N  Yam, M F  Abdullah, W O  Abdul Majid, R 
Citation: Fazalul Rahiman SS, etal., Trop Biomed. 2013 Dec;30(4):663-80.
RGD ID: 126790512
Pubmed: PMID:24522137   (View Abstract at PubMed)

Interleukin-27 (IL-27) has a pleiotropic role either as a pro-inflammatory or anti-inflammatory cytokine in inflammatory related diseases. The role and involvement of IL-27 during malaria was investigated and the effects of modulating its release on the production of major inflammatory cytokines and the histopathological consequences in major affected organs during the infection were evaluated. Results showed that IL-27 concentration was significantly elevated throughout the infection but no positive correlation with the parasitaemia development observed. Augmentation of IL-27 significantly elevated the release of anti-inflammatory cytokine, IL-10 whereas antagonising and neutralising IL-27 produced the opposite. A significant elevation of pro-inflammatory cytokines (IFN-γ and IL-6) was also observed, both during augmentation and inhibition of IL-27. Thus, it is suggested that IL-27 exerts an anti-inflammatory activity in the Th1 type response by signalling the production of IL-10 during malaria. Histopathological examination showed sequestration of PRBC in the microvasculature of major organs in malarial mice. Other significant histopathological changes include hyperplasia and hypertrophy of the Kupffer cells in the liver, hyaline membrane formation in lung tissue, enlargement of the white and red pulp followed by the disappearance of germinal centre of the spleen, and tubular vacuolation of the kidney tissues. In conclusion, it is suggested that IL-27 may possibly acts as an anti-inflammatory cytokine during the infection. Modulation of its release produced a positive impact on inflammatory cytokine production during the infection, suggesting its potential in malaria immunotherapy, in which the host may benefit from its inhibition.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
malaria  ISOIl27 (Mus musculus)126790512; 126790512 RGD 
malaria  IMP 126790512 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information