RGD Reference Report - Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. - Rat Genome Database

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Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement.

Authors: Huang, Mingyuan  Du, Wenjing  Liu, Jun  Zhang, Haiyang  Cao, Longbin  Yang, Weiqing  Zhang, Hui  Wang, Zhiyong  Wei, Pei  Wu, Weiquan  Huang, Zhulin  Fang, Ying  Lin, Qiling  Qin, Xingwen  Zhang, Zhizhong  Zhou, Keyuan  Zeng, Jincheng 
Citation: Huang M, etal., Mediators Inflamm. 2016;2016:4025167. doi: 10.1155/2016/4025167. Epub 2016 Jun 15.
RGD ID: 126790503
Pubmed: PMID:27403033   (View Abstract at PubMed)
PMCID: PMC4925946   (View Article at PubMed Central)
DOI: DOI:10.1155/2016/4025167   (Journal Full-text)

Enterovirus 71 (EV71) is a major pathogen for severe hand, foot, and mouth disease (HFMD), which leads to severe neurological complications and has high morbidity and mortality. Reliable biomarker for the prediction of deterioration in EV71-infected children with central nervous system (CNS) involvement may reduce the cardiopulmonary failure and mortality. Here, we found that serum IL-27 levels were significantly higher in stage III EV71-infected HFMD patients with early cardiopulmonary failure and strong correlation with CRP levels. IL27p28 polymorphisms (rs153109, rs17855750, and rs181206) did not influence IL-27 production, and these three SNPs were not associated with EV71 infection risk and clinical stage. IL-27 can be used as an prediction indicator for early cardiopulmonary failure in EV71-infected children with CNS involvement.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cor pulmonale disease_progressionIEP 126790503associated with hand more ...RGD 
Cor pulmonale disease_progressionISOIL27 (Homo sapiens)126790503; 126790503associated with hand more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information