RGD Reference Report - Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. - Rat Genome Database

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Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia.

Authors: Cao, J  Wang, D  Xu, F  Gong, Y  Wang, H  Song, Z  Li, D  Zhang, H  Li, D  Zhang, L  Xia, Y  Xu, H  Lai, X  Lin, S  Zhang, X  Ren, G  Dai, Y  Yin, Y 
Citation: Cao J, etal., EMBO Mol Med. 2014 Jan;6(1):120-40. doi: 10.1002/emmm.201302890.
RGD ID: 11556418
Pubmed: PMID:24408967   (View Abstract at PubMed)
PMCID: PMC3936494   (View Article at PubMed Central)
DOI: DOI:10.1002/emmm.201302890   (Journal Full-text)

Postinfluenza pneumococcal pneumonia is a common cause of death in humans. However, the role of IL-27 in the pathogenesis of secondary pneumococcal pneumonia after influenza is unknown. We now report that influenza infection induced pulmonary IL-27 production in a type I IFN-alpha/beta receptor (IFNAR) signalling-dependent manner, which sensitized mice to secondary pneumococcal infection downstream of IFNAR pathway. Mice deficient in IL-27 receptor were resistant to secondary pneumococcal infection and generated more IL-17A-producing gammadelta T cells but not alphabeta T cells, thereby leading to enhanced neutrophil response during the early phase of host defence. IL-27 treatment could suppress the development of IL-17A-producing gammadelta T cells activated by Streptococcus pneumoniae and dendritic cells. This suppressive activity of IL-27 on gammadelta T cells was dependent on transcription factor STAT1. Finally, neutralization of IL-27 or administration of IL-17A restored the role of gammadelta T cells in combating secondary pneumococcal infection. Our study defines what we believe to be a novel role of IL-27 in impairing host innate immunity against pneumococcal infection.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Pneumococcal Infections  ISOIl27 (Mus musculus)11556418; 11556418associated with influenza A and protein:increased expression:lung (mouse)RGD 
Pneumococcal Infections  IEP 11556418associated with influenza A and protein:increased expression:lung (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)

Additional Information