RGD Reference Report - Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. - Rat Genome Database

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Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability.

Authors: Paul, VD  Lill, R 
Citation: Paul VD and Lill R, Biochim Biophys Acta. 2015 Jun;1853(6):1528-39. doi: 10.1016/j.bbamcr.2014.12.018. Epub 2015 Jan 10.
RGD ID: 11554192
Pubmed: PMID:25583461   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbamcr.2014.12.018   (Journal Full-text)

Iron-sulfur (Fe-S) clusters are versatile protein cofactors that require numerous components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of cytosolic and nuclear Fe-S proteins is accomplished by cooperation of the mitochondrial iron-sulfur cluster (ISC) assembly and export machineries, and the cytosolic iron-sulfur protein assembly (CIA) system. Currently, nine CIA proteins are known to specifically assist the two major steps of the biogenesis reaction. They are essential for cell viability and conserved from yeast to man. The essential character of this biosynthetic process is explained by the involvement of Fe-S proteins in central processes of life, e.g., protein translation and numerous steps of nuclear DNA metabolism such as DNA replication and repair. Malfunctioning of these latter Fe-S enzymes leads to genome instability, a hallmark of cancer. This review is focused on the maturation and biological function of cytosolic and nuclear Fe-S proteins, a topic of central interest for both basic and medical research. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CIAO1Humancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
CIAO2AHumancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
CIAO2BHumancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
CIAO3Humancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
CIAPIN1Humancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
Ciao1Ratcytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO1 (Homo sapiens) RGD 
Ciao1Mousecytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO1 (Homo sapiens) RGD 
Ciao2aRatcytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO2A (Homo sapiens) RGD 
Ciao2aMousecytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO2A (Homo sapiens) RGD 
Ciao2bMousecytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO2B (Homo sapiens) RGD 
Ciao2bRatcytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO2B (Homo sapiens) RGD 
Ciao3Ratcytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO3 (Homo sapiens) RGD 
Ciao3Mousecytosolic iron-sulfur cluster protein assembly pathway   ISOCIAO3 (Homo sapiens) RGD 
Ciapin1Ratcytosolic iron-sulfur cluster protein assembly pathway   ISOCIAPIN1 (Homo sapiens) RGD 
Ciapin1Mousecytosolic iron-sulfur cluster protein assembly pathway   ISOCIAPIN1 (Homo sapiens) RGD 
MMS19Humancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
Mms19Ratcytosolic iron-sulfur cluster protein assembly pathway   ISOMMS19 (Homo sapiens) RGD 
Mms19Mousecytosolic iron-sulfur cluster protein assembly pathway   ISOMMS19 (Homo sapiens) RGD 
NDOR1Humancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
NUBP1Humancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
NUBP2Humancytosolic iron-sulfur cluster protein assembly pathway   TAS  RGD 
Ndor1Ratcytosolic iron-sulfur cluster protein assembly pathway   ISONDOR1 (Homo sapiens) RGD 
Ndor1Mousecytosolic iron-sulfur cluster protein assembly pathway   ISONDOR1 (Homo sapiens) RGD 
Nubp1Ratcytosolic iron-sulfur cluster protein assembly pathway   ISONUBP1 (Homo sapiens) RGD 
Nubp1Mousecytosolic iron-sulfur cluster protein assembly pathway   ISONUBP1 (Homo sapiens) RGD 
Nubp2Ratcytosolic iron-sulfur cluster protein assembly pathway   ISONUBP2 (Homo sapiens) RGD 
Nubp2Mousecytosolic iron-sulfur cluster protein assembly pathway   ISONUBP2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ciao1  (cytosolic iron-sulfur assembly component 1)
Ciao2a  (cytosolic iron-sulfur assembly component 2A)
Ciao2b  (cytosolic iron-sulfur assembly component 2B)
Ciao3  (cytosolic iron-sulfur assembly component 3)
Ciapin1  (cytokine induced apoptosis inhibitor 1)
Mms19  (MMS19 homolog, cytosolic iron-sulfur assembly component)
Ndor1  (NADPH dependent diflavin oxidoreductase 1)
Nubp1  (NUBP iron-sulfur cluster assembly factor 1)
Nubp2  (NUBP iron-sulfur cluster assembly factor 2)

Genes (Mus musculus)
Ciao1  (cytosolic iron-sulfur protein assembly 1)
Ciao2a  (cytosolic iron-sulfur assembly component 2A)
Ciao2b  (cytosolic iron-sulfur assembly component 2B)
Ciao3  (cytosolic iron-sulfur assembly component 3)
Ciapin1  (cytokine induced apoptosis inhibitor 1)
Mms19  (MMS19 cytosolic iron-sulfur assembly component)
Ndor1  (NADPH dependent diflavin oxidoreductase 1)
Nubp1  (nucleotide binding protein 1)
Nubp2  (nucleotide binding protein 2)

Genes (Homo sapiens)
CIAO1  (cytosolic iron-sulfur assembly component 1)
CIAO2A  (cytosolic iron-sulfur assembly component 2A)
CIAO2B  (cytosolic iron-sulfur assembly component 2B)
CIAO3  (cytosolic iron-sulfur assembly component 3)
CIAPIN1  (cytokine induced apoptosis inhibitor 1)
MMS19  (MMS19 homolog, cytosolic iron-sulfur assembly component)
NDOR1  (NADPH dependent diflavin oxidoreductase 1)
NUBP1  (NUBP iron-sulfur cluster assembly factor 1, cytosolic)
NUBP2  (NUBP iron-sulfur cluster assembly factor 2, cytosolic)


Additional Information