RGD Reference Report - High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma. - Rat Genome Database

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High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma.

Authors: Han, F  Liu, W  Xiao, H  Dong, Y  Sun, L  Mao, C  Yin, L  Jiang, X  Ao, L  Cui, Z  Cao, J  Liu, J 
Citation: Han F, etal., Sci Rep. 2015 Sep 2;5:13630. doi: 10.1038/srep13630.
RGD ID: 11535423
Pubmed: PMID:26330328   (View Abstract at PubMed)
PMCID: PMC4557060   (View Article at PubMed Central)
DOI: DOI:10.1038/srep13630   (Journal Full-text)

In our previous study, we had identified SOX30 as a novel tumor suppressor that acts through direct regulation of p53 transcription in human lung cancer. Here, we sought to determine the clinical relevance of SOX30 expression in a series of surgically-resected non-small cell lung cancer (NSCLC) patients. Analysis of SOX30 expression and clinico-pathologic features reveal a significant correlation of SOX30 expression with histological type (n = 220, P = 0.008) and clinical stage (n = 220, P = 0.024). Kaplan-Meier analysis indicates an association of high SOX30 expression with better prognosis in NSCLC patients (n = 220, P = 0.007). Via multivariate Cox-regression analysis, SOX30 expression is revealed to be an independent prognostic factor for overall survival (OS) of NSCLC patients (n = 220, P = 0.014, hazard ratio (HR) = 0.816). In particular, SOX30 is a favorable and independent prognostic factor in one main subtype of NSCLC, lung adenocarcinoma (ADC) patients (n = 150, P = 0.000, HR = 0.405), but not in another main subtype of NSCLC, squamous cell carcinoma patients. Furthermore, high expression of SOX30 represents a favorable and independent factor for the prognosis of ADC patients at clinical stage II (P = 0.013), with positive lymph node (P = 0.003), at histological grade 2 (P = 0.000) or grade 3 (P = 0.025). In summary, SOX30 expression represents an important prognostic factor for survival time in ADC patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SOX30Humanlung adenocarcinoma disease_progressionIEP  RGD 
Sox30Mouselung adenocarcinoma disease_progressionISOSOX30 (Homo sapiens) RGD 
Sox30Ratlung adenocarcinoma disease_progressionISOSOX30 (Homo sapiens) RGD 
SOX30Humanlung squamous cell carcinoma disease_progressionIEP  RGD 
Sox30Mouselung squamous cell carcinoma disease_progressionISOSOX30 (Homo sapiens) RGD 
Sox30Ratlung squamous cell carcinoma disease_progressionISOSOX30 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sox30  (SRY-box transcription factor 30)

Genes (Mus musculus)
Sox30  (SRY (sex determining region Y)-box 30)

Genes (Homo sapiens)
SOX30  (SRY-box transcription factor 30)


Additional Information