RGD Reference Report - PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer. - Rat Genome Database

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PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer.

Authors: Lian, S  Shao, Y  Liu, H  He, J  Lu, W  Zhang, Y  Jiang, Y  Zhu, J 
Citation: Lian S, etal., Oncotarget. 2015 Oct 6;6(30):29076-86. doi: 10.18632/oncotarget.4931.
RGD ID: 11528126
Pubmed: PMID:26318166   (View Abstract at PubMed)
PMCID: PMC4745712   (View Article at PubMed Central)
DOI: DOI:10.18632/oncotarget.4931   (Journal Full-text)

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
JUNBHumangallbladder cancer exacerbatesIEP protein:increased expression:gall bladder (human)RGD 
JunbRatgallbladder cancer exacerbatesISOJUNB (Homo sapiens)protein:increased expression:gall bladder (human)RGD 
JunbMousegallbladder cancer exacerbatesISOJUNB (Homo sapiens)protein:increased expression:gall bladder (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Junb  (JunB proto-oncogene, AP-1 transcription factor subunit)

Genes (Mus musculus)
Junb  (jun B proto-oncogene)

Genes (Homo sapiens)
JUNB  (JunB proto-oncogene, AP-1 transcription factor subunit)


Additional Information