RGD Reference Report - A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor. - Rat Genome Database

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A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor.

Authors: Erez, O  Espinoza, J  Chaiworapongsa, T  Gotsch, F  Kusanovic, JP  Than, NG  Mazaki-Tovi, S  Vaisbuch, E  Papp, Z  Yoon, BH  Han, YM  Hoppensteadt, D  Fareed, J  Hassan, SS  Romero, R 
Citation: Erez O, etal., J Matern Fetal Neonatal Med. 2008 Oct;21(10):732-44. doi: 10.1080/14767050802361807.
RGD ID: 11340215
Pubmed: PMID:19012190   (View Abstract at PubMed)
PMCID: PMC2887664   (View Article at PubMed Central)
DOI: DOI:10.1080/14767050802361807   (Journal Full-text)

OBJECTIVE: Vaginal bleeding is a risk factor for preterm PROM (PPROM). A disorder of decidual hemostasis has been implicated in the genesis of PROM. Indeed, excessive thrombin generation has been demonstrated in PPROM both before and at the time of diagnosis. Decidua is a potent source of tissue factor (TF), the most powerful natural pro-coagulant. A decidual hemostatic disorder may link vaginal bleeding, PPROM and placental abruption. This study was conducted to determine the behaviour of maternal TF and its natural inhibitor, the tissue factor pathway inhibitor (TFPI) in PPROM. METHODS: This cross-sectional study included women with PPROM (n = 123) and women with normal pregnancies (n = 86). Plasma concentrations of TF and TFPI were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis. RESULTS: (1) The median maternal plasma TF concentration was significantly higher in patients with PPROM than in women with normal pregnancies (median: 369.5 pg/mL; range: 3.27-2551 pg/mL vs. median: 291.5 pg/mL; range: 6.3-2662.2 pg/mL respectively, p = 0.001); (2) the median maternal TFPI plasma concentration was significantly lower in patients with PPROM than in women with normal pregnancies (median: 58.7 ng/mL; range: 26.3-116 ng/mL vs. median: 66.1 ng/mL; range: 14.3-86.5 ng/mL respectively, p = 0.019); (3) there was no correlation between the plasma concentration of TF and TFPI and the gestational age at sample collection; and (4) among patients with PPROM there was no association between the presence of intra-amniotic infection or inflammation and median plasma concentrations of TF and TFPI. CONCLUSIONS: (1) Patients with PPROM have a higher median plasma concentration of TF and a lower median plasma concentration of TFPI than women with normal pregnancies. (2) These findings suggest that PPROM is associated with specific changes in the hemostatic/coagulation system.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F3Ratpreterm premature rupture of the membranes  ISOF3 (Homo sapiens)protein:increased expression:plasmaRGD 
F3Humanpreterm premature rupture of the membranes  IEP protein:increased expression:plasmaRGD 
F3Mousepreterm premature rupture of the membranes  ISOF3 (Homo sapiens)protein:increased expression:plasmaRGD 
TFPIHumanpreterm premature rupture of the membranes  IEP protein:decreased expression:plasmaRGD 
TfpiRatpreterm premature rupture of the membranes  ISOTFPI (Homo sapiens)protein:decreased expression:plasmaRGD 
TfpiMousepreterm premature rupture of the membranes  ISOTFPI (Homo sapiens)protein:decreased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
F3  (coagulation factor III, tissue factor)
Tfpi  (tissue factor pathway inhibitor)

Genes (Mus musculus)
F3  (coagulation factor III)
Tfpi  (tissue factor pathway inhibitor)

Genes (Homo sapiens)
F3  (coagulation factor III, tissue factor)
TFPI  (tissue factor pathway inhibitor)


Additional Information