RGD Reference Report - Promoter methylation of P15(INK4B) gene is possibly associated with parvovirus B19 infection in adult acute leukemias. - Rat Genome Database

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Promoter methylation of P15(INK4B) gene is possibly associated with parvovirus B19 infection in adult acute leukemias.

Authors: YALCIN, A  Serin, MS  Emekdas, G  Tiftik, N  Aslan, G  Eskandari, G  Tezcan, S 
Citation: Yalcin A, etal., Int J Lab Hematol. 2009 Aug;31(4):407-19. doi: 10.1111/j.1751-553X.2008.01052.x. Epub 2008 Apr 1.
RGD ID: 11252189
Pubmed: PMID:18384396   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1751-553X.2008.01052.x   (Journal Full-text)

In this study, we examined the P15(INK4B) gene promoter methylation in patients with myelodysplastic syndrome and acute leukemia and its possible relationship with parvovirus B19 and Epstein-Barr virus infections. P15(INK4B) methylation frequency was significantly higher in acute leukemia patients than in that of non-malignant patients (P < 0.05). When the patients with myelodysplastic syndrome were included, no significant difference was found between these groups regarding the methylation status. The possible correlation between P15(INK4B) promoter methylation and parvovirus B19 infection was observed in adult acute leukemia patients (P < 0.05). However, no similar relationship in EBV-infected patients was observed. To the best of our knowledge, this is the first report showing the possible association between P15(INK4B) promoter methylation and parvovirus B19 infection in acute leukemia.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDKN2BHumanerythema infectiosum  IDA associated with Leukemia more ...RGD 
Cdkn2bRaterythema infectiosum  ISOCDKN2B (Homo sapiens)associated with Leukemia more ...RGD 
Cdkn2bMouseerythema infectiosum  ISOCDKN2B (Homo sapiens)associated with Leukemia more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn2b  (cyclin-dependent kinase inhibitor 2B)

Genes (Mus musculus)
Cdkn2b  (cyclin dependent kinase inhibitor 2B)

Genes (Homo sapiens)
CDKN2B  (cyclin dependent kinase inhibitor 2B)


Additional Information