RGD Reference Report - The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses. - Rat Genome Database

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The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses.

Authors: Raghavendran, K  Davidson, BA  Woytash, JA  Helinski, JD  Marschke, CJ  Manderscheid, PA  Notter, RH  Knight, PR 
Citation: Raghavendran K, etal., Shock. 2005 Aug;24(2):132-8.
RGD ID: 11060268
Pubmed: PMID:16044083   (View Abstract at PubMed)
PMCID: PMC3034634   (View Article at PubMed Central)

Lung contusion is the leading cause of death from blunt thoracic trauma in adults, but its mechanistic pathophysiology remains unclear. This study uses a recently developed rat model to investigate the evolution of inflammation and injury in isolated lung contusion. Bilateral lung contusion with minimal cardiac trauma was induced in 54 anesthetized rats by dropping a 0.3-kg hollow cylindrical weight onto a precordial shield (impact energy, 2.45 Joules). Arterial oxygenation, pressure-volume (P-V) mechanics, histology, and levels of erythrocytes, leukocytes, albumin, and inflammatory mediators in bronchoalveolar lavage (BAL) were assessed at 8 min, at 4, 12, 24, and 48 h, and at 7 days after injury. The role of neutrophils in the evolution of inflammatory injury was also specifically studied by depleting these cells with intravenous vinblastine before lung contusion. Arterial oxygenation was severely reduced at 8 min to 24 h postcontusion, but became almost normal by 48 h. Levels of erythrocytes, leukocytes, and albumin in BAL were increased at



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL2HumanPulmonary Contusion  ISOCcl2 (Rattus norvegicus)protein:increased expression:alveolar system (rat)RGD 
Ccl2RatPulmonary Contusion  IEP protein:increased expression:alveolar system (rat)RGD 
Ccl2MousePulmonary Contusion  ISOCcl2 (Rattus norvegicus)protein:increased expression:alveolar system (rat)RGD 
IL6HumanPulmonary Contusion  ISOIl6 (Rattus norvegicus)protein:increased expression:bronchoalveolar lavage fluid (rat)RGD 
Il6RatPulmonary Contusion  IEP protein:increased expression:bronchoalveolar lavage fluid (rat)RGD 
Il6MousePulmonary Contusion  ISOIl6 (Rattus norvegicus)protein:increased expression:bronchoalveolar lavage fluid (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)
Il6  (interleukin 6)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)
Il6  (interleukin 6)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)
IL6  (interleukin 6)


Additional Information