RGD Reference Report - Peripheral inflammatory activation after hippocampus irradiation in the rat. - Rat Genome Database

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Peripheral inflammatory activation after hippocampus irradiation in the rat.

Authors: Tokes, T  Varga, G  Garab, D  Nagy, Z  Fekete, G  Tuboly, E  Plangar, I  Man, I  Szabo, RE  Szabo, Z  Volford, G  Ghyczy, M  Kaszaki, J  Boros, M  Hideghety, K 
Citation: Tokes T, etal., Int J Radiat Biol. 2014 Jan;90(1):1-6. doi: 10.3109/09553002.2013.836617. Epub 2013 Sep 13.
RGD ID: 11049496
Pubmed: PMID:23968122   (View Abstract at PubMed)
DOI: DOI:10.3109/09553002.2013.836617   (Journal Full-text)

PURPOSE: To detect the possible biochemical signs of inflammatory activation in the peripheral circulation in a rodent model of hippocampus irradiation, and to examine the effects of L-alpha-glycerylphosphorylcholine (GPC) in this experimental protocol. MATERIALS AND METHODS: Anesthetized Sprague-Dawley rats were subjected to 40 Gy cobalt irradiation of both hemispheres of the hippocampus, with or without GPC treatment (50 mg/kg intravenously (i.v.), 5 min before the irradiation, n = 6, each). A third group (n = 6) served as saline-treated control. Blood samples were obtained 3 h after the end of irradiation in order to examine the changes in plasma histamine, tumor necrosis factor-alpha (TNF-alpha), interleukin 1-beta, interleukin 6 (IL-6) and interleukin 10 (IL-10); liver tissue samples were taken to determine adenosine triphosphate (ATP) concentrations. RESULTS: The hepatic ATP levels were significantly declined, while plasma concentrations of circulating TNF-alpha, IL-6, IL-10 and histamine were significantly increased after hippocampus irradiation. GPC treatment significantly reduced the irradiation-induced release of cytokines and histamine, and the liver ATP level was maintained at the control value. CONCLUSIONS: Targeted brain irradiation produced measurable pro- and anti-inflammatory cytokine changes in the systemic circulation. GPC supplementation provides significant protection against irradiation-induced peripheral pro-inflammatory activation and ATP depletion.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL10HumanExperimental Radiation Injuries  ISOIl10 (Rattus norvegicus)protein:increased expression:plasmaRGD 
Il10RatExperimental Radiation Injuries  IEP protein:increased expression:plasmaRGD 
Il10MouseExperimental Radiation Injuries  ISOIl10 (Rattus norvegicus)protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information