RGD Reference Report - Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. - Rat Genome Database

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Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma.

Authors: Wreesmann, VB  Estilo, C  Eisele, DW  Singh, B  Wang, SJ 
Citation: Wreesmann VB, etal., ORL J Otorhinolaryngol Relat Spec. 2007;69(4):218-25. Epub 2007 Apr 4.
RGD ID: 11049143
Pubmed: PMID:17409780   (View Abstract at PubMed)
DOI: DOI:10.1159/000101542   (Journal Full-text)

BACKGROUND/AIMS: Much of our understanding of human cancer has come from studies of the hereditary cancer predisposition syndromes. Fanconi anemia (FA) is an autosomal recessive disorder characterized by cellular hypersensitivity to DNA crosslinking agents, progressive bone marrow failure, and cancer predisposition to solid malignancies, especially head and neck squamous cell carcinoma (HNSCC). Since FA pathway-deficient cells are hypersensitive to DNA crosslinking chemotherapy agents, the presence of somatic FA gene inactivation in sporadic cancers may be of clinical interest. This study sought to determine the frequency of FA gene downregulation in sporadic HNSCC. METHODS: The expression of the FA genes FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCJ, FANCL and FANCM in 11 HNSCC cell lines and 49 tongue carcinoma samples was studied with quantitative real-time polymerase chain reaction. RESULTS: Downregulation of at least one FA gene was observed in 3 of 11 HNSCC cell lines and 66% of tongue carcinoma samples. FANCB, FANCF, FANCJ and FANCM were most commonly affected by downregulation, whereas downregulation of FANCA, FANCE and FANCD2 was rare. CONCLUSION: Our data suggest that downregulation of FA genes is common in sporadic HNSCC. The clinical implications of this finding merit further study. .



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FANCBHumantongue squamous cell carcinoma  IEP  RGD 
FANCCHumantongue squamous cell carcinoma  IEP  RGD 
FANCFHumantongue squamous cell carcinoma  IEP mRNA:decreased expression:tongue:RGD 
FANCGHumantongue squamous cell carcinoma  IEP  RGD 
FANCIHumantongue squamous cell carcinoma  IEP  RGD 
FANCLHumantongue squamous cell carcinoma  IEP  RGD 
FANCMHumantongue squamous cell carcinoma  IEP  RGD 
FancbRattongue squamous cell carcinoma  ISOFANCB (Homo sapiens) RGD 
FancbMousetongue squamous cell carcinoma  ISOFANCB (Homo sapiens) RGD 
FanccRattongue squamous cell carcinoma  ISOFANCC (Homo sapiens) RGD 
FanccMousetongue squamous cell carcinoma  ISOFANCC (Homo sapiens) RGD 
FancfRattongue squamous cell carcinoma  ISOFANCF (Homo sapiens)mRNA:decreased expression:tongue:RGD 
FancfMousetongue squamous cell carcinoma  ISOFANCF (Homo sapiens)mRNA:decreased expression:tongue:RGD 
FancgRattongue squamous cell carcinoma  ISOFANCG (Homo sapiens) RGD 
FancgMousetongue squamous cell carcinoma  ISOFANCG (Homo sapiens) RGD 
FanciMousetongue squamous cell carcinoma  ISOFANCI (Homo sapiens) RGD 
FanciRattongue squamous cell carcinoma  ISOFANCI (Homo sapiens) RGD 
FanclRattongue squamous cell carcinoma  ISOFANCL (Homo sapiens) RGD 
FanclMousetongue squamous cell carcinoma  ISOFANCL (Homo sapiens) RGD 
FancmRattongue squamous cell carcinoma  ISOFANCM (Homo sapiens) RGD 
FancmMousetongue squamous cell carcinoma  ISOFANCM (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fancb  (FA complementation group B)
Fancc  (FA complementation group C)
Fancf  (FA complementation group F)
Fancg  (FA complementation group G)
Fanci  (FA complementation group I)
Fancl  (FA complementation group L)
Fancm  (FA complementation group M)

Genes (Mus musculus)
Fancb  (Fanconi anemia, complementation group B)
Fancc  (Fanconi anemia, complementation group C)
Fancf  (Fanconi anemia, complementation group F)
Fancg  (Fanconi anemia, complementation group G)
Fanci  (Fanconi anemia, complementation group I)
Fancl  (Fanconi anemia, complementation group L)
Fancm  (Fanconi anemia, complementation group M)

Genes (Homo sapiens)
FANCB  (FA complementation group B)
FANCC  (FA complementation group C)
FANCF  (FA complementation group F)
FANCG  (FA complementation group G)
FANCI  (FA complementation group I)
FANCL  (FA complementation group L)
FANCM  (FA complementation group M)


Additional Information