RGD Reference Report - Reduced expression of the interferon-gamma messenger RNA in IgG2 deficiency. - Rat Genome Database

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Reduced expression of the interferon-gamma messenger RNA in IgG2 deficiency.

Authors: Kondo, N  Inoue, R  Kasahara, K  Fukao, T  Kaneko, H  Tashita, H  Teramoto, T 
Citation: Kondo N, etal., Scand J Immunol. 1997 Feb;45(2):227-30.
RGD ID: 10755693
Pubmed: PMID:9042436   (View Abstract at PubMed)

The specific defect that causes IgG2 deficiency, which is one of the primary immunodeficiencies, is unknown. Recently, it was shown that interferon-gamma (IFN-gamma) induces synthesis of human germline C gamma 2 transcripts. In the authors' previous study and the present one, peripheral blood lymphocytes (PBLs) of all five tested patients with IgG2 deficiency failed to produce enough IFN-gamma when stimulated with phytohaemagglutinin or concanavalin A although they produced a sufficient amount of interleukin-2 (IL-2). The low level of IgG2 production in pokeweed mitogen-stimulated PBLs of four tested patients was improved by the addition of recombinant IFN-gamma. In this study, the amount of IFN-gamma messenger RNA showed various degrees of reduction in all five tested patients. Sequence analysis of the IFN-gamma coding regions and flanking regions revealed neither a point mutation nor a deletion for any of the patients. Thus the results suggest that the reduced expression of IFN-gamma messenger RNA may play an important role in the IgG2 deficiency of these patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IFNGHumanselective IgG deficiency disease  IEP mRNA:decreased expression:peripheral blood leukocyte:RGD 
IfngRatselective IgG deficiency disease  ISOIFNG (Homo sapiens)mRNA:decreased expression:peripheral blood leukocyte:RGD 
IfngMouseselective IgG deficiency disease  ISOIFNG (Homo sapiens)mRNA:decreased expression:peripheral blood leukocyte:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)

Genes (Mus musculus)
Ifng  (interferon gamma)

Genes (Homo sapiens)
IFNG  (interferon gamma)


Additional Information