RGD Reference Report - New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. - Rat Genome Database

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New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.

Authors: Sasaki, D  Kotoh, J  Watadani, R  Matsumoto, K 
Citation: Sasaki D, etal., Mamm Genome. 2015 Dec;26(11-12):619-29. doi: 10.1007/s00335-015-9597-4. Epub 2015 Aug 22.
RGD ID: 10755343
Pubmed: PMID:26296322   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-015-9597-4   (Journal Full-text)

Obesity is a major risk factor for the onset of type 2 diabetes; however, little is known about the gene(s) involved. Therefore, we developed new animal models of obesity to search for diabetogenic genes associated with obesity. We generated double congenic rat strains with a hyperglycaemic quantitative trait locus (QTL) derived from the Otsuka Long-Evans Tokushima Fatty rat and a fa/fa (Lepr (-/-)) locus derived from the Zucker Fatty rat; phenotypic analysis for plasma glucose and insulin levels and RNA and protein levels were determined using reverse transcription quantitative PCR and Western blotting analyses, respectively. The double congenic strain F344-fa-nidd2 (Lepr (-/-) and Nidd2/of) exhibited significantly higher glucose levels and significantly lower hypoglycaemic response to insulin than the obese control strain F344-fa (Lepr (-/-)). These phenotypes were clearly observed in the obese strains but not in the lean strains. These results indicate that the Nidd2/of locus harbours a diabetogenic gene associated with obesity. We measured the expression of 60 genes in the Nidd2/of QTL region between the strains and found that the mRNA expression levels of five genes were significantly different between the strains under the condition of obesity. However, three of the five genes were differentially expressed in both obese and lean rats, indicating that these genes are not specific for the condition of obesity. Conversely, the other two genes, coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8), were differentially expressed only in the obese rats, suggesting that these two genes are candidates for the onset of type 2 diabetes associated with obesity in rats.



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Phenotype Annotations    

Mammalian Phenotype

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Strains with Phenominer Data Strains with phenominer dataStrains with phenominer data
F344.ZUC-Leprfa/Tj F344/NSlc F344.OLETF-(D14Rat23-D14Rat12)/Tj
F344.ZUC-(Leprfa),OLETF-(D14Rat23-D14Rat12)/Tj

Objects Annotated

Genes (Rattus norvegicus)
Coq2  (coenzyme Q2, polyprenyltransferase)
Plac8  (placenta associated 8)

Genes (Mus musculus)
Coq2  (coenzyme Q2 4-hydroxybenzoate polyprenyltransferase)
Plac8  (placenta-specific 8)

Genes (Homo sapiens)
COQ2  (coenzyme Q2, polyprenyltransferase)
PLAC8  (placenta associated 8)

Objects referenced in this article
Strain F344/NSlc null Rattus norvegicus
QTL Niddm20 Non-insulin dependent diabetes mellitus QTL 20 Rattus norvegicus

Additional Information