RGD Reference Report - Genes associated with Parkinson's disease: regulation of autophagy and beyond. - Rat Genome Database

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Genes associated with Parkinson's disease: regulation of autophagy and beyond.

Authors: Beilina, A  Cookson, MR 
Citation: Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
RGD ID: 10450518
Pubmed: PMID:26223426   (View Abstract at PubMed)
PMCID: PMC5834228   (View Article at PubMed Central)
DOI: DOI:10.1111/jnc.13266   (Journal Full-text)

Substantial progress has been made in the genetic basis of Parkinson's disease (PD). In particular, by identifying genes that segregate with inherited PD or show robust association with sporadic disease, and by showing the same genes are found on both lists, we have generated an outline of the cause of this condition. Here, we will discuss what those genes tell us about the underlying biology of PD. We specifically discuss the relationships between protein products of PD genes and show that common links include regulation of the autophagy-lysosome system, an important way by which cells recycle proteins and organelles. We also discuss whether all PD genes should be considered to be in the same pathway and propose that in some cases the relationships are closer, whereas in other cases the interactions are more distant and might be considered separate. Beilina and Cookson review the links between genes for Parkinson's disease (red) and the autophagy-lysosomal system. They propose the hypothesis that many of the known PD genes can be assigned to pathways that affect (I) turnover of mitochondria via mitophagy (II) turnover of several vesicular structures via macroautophagy or chaperone-mediated autophagy or (III) general lysosome function.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATP13A2HumanParkinson's disease pathway   TAS  RGD 
Atp13a2MouseParkinson's disease pathway   ISOATP13A2 (Homo sapiens) RGD 
Atp13a2RatParkinson's disease pathway   ISOATP13A2 (Homo sapiens) RGD 
FBXO7HumanParkinson's disease pathway   TAS  RGD 
Fbxo7MouseParkinson's disease pathway   ISOFBXO7 (Homo sapiens) RGD 
Fbxo7RatParkinson's disease pathway   ISOFBXO7 (Homo sapiens) RGD 
GBA1HumanParkinson's disease pathway   TAS  RGD 
Gba1MouseParkinson's disease pathway   ISOGBA1 (Homo sapiens) RGD 
Gba1RatParkinson's disease pathway   ISOGBA1 (Homo sapiens) RGD 
LRRK2HumanParkinson's disease pathway   TAS  RGD 
Lrrk2RatParkinson's disease pathway   ISOLRRK2 (Homo sapiens) RGD 
Lrrk2MouseParkinson's disease pathway   ISOLRRK2 (Homo sapiens) RGD 
PINK1HumanParkinson's disease pathway   TAS  RGD 
PRKNHumanParkinson's disease pathway   TAS  RGD 
Pink1MouseParkinson's disease pathway   ISOPINK1 (Homo sapiens) RGD 
Pink1RatParkinson's disease pathway   ISOPINK1 (Homo sapiens) RGD 
PrknMouseParkinson's disease pathway   ISOPRKN (Homo sapiens) RGD 
PrknRatParkinson's disease pathway   ISOPRKN (Homo sapiens) RGD 
SNCAHumanParkinson's disease pathway   TAS  RGD 
SncaMouseParkinson's disease pathway   ISOSNCA (Homo sapiens) RGD 
SncaRatParkinson's disease pathway   ISOSNCA (Homo sapiens) RGD 
VPS35HumanParkinson's disease pathway   TAS  RGD 
Vps35MouseParkinson's disease pathway   ISOVPS35 (Homo sapiens) RGD 
Vps35RatParkinson's disease pathway   ISOVPS35 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Atp13a2  (ATPase cation transporting 13A2)
Fbxo7  (F-box protein 7)
Gba1  (glucosylceramidase beta 1)
Lrrk2  (leucine-rich repeat kinase 2)
Pink1  (PTEN induced kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)
Snca  (synuclein alpha)
Vps35  (VPS35 retromer complex component)

Genes (Mus musculus)
Atp13a2  (ATPase type 13A2)
Fbxo7  (F-box protein 7)
Gba1  (glucosylceramidase beta 1)
Lrrk2  (leucine-rich repeat kinase 2)
Pink1  (PTEN induced putative kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)
Snca  (synuclein, alpha)
Vps35  (VPS35 retromer complex component)

Genes (Homo sapiens)
ATP13A2  (ATPase cation transporting 13A2)
FBXO7  (F-box protein 7)
GBA1  (glucosylceramidase beta 1)
LRRK2  (leucine rich repeat kinase 2)
PINK1  (PTEN induced kinase 1)
PRKN  (parkin RBR E3 ubiquitin protein ligase)
SNCA  (synuclein alpha)
VPS35  (VPS35 retromer complex component)


Additional Information