RGD Reference Report - Unlocking the presequence import pathway. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Unlocking the presequence import pathway.

Authors: Schulz, C  Schendzielorz, A  Rehling, P 
Citation: Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
RGD ID: 10412659
Pubmed: PMID:25542066   (View Abstract at PubMed)
DOI: DOI:10.1016/j.tcb.2014.12.001   (Journal Full-text)

Translocation of presequence-containing precursor proteins into the inner mitochondrial membrane and matrix is an essential process that is facilitated by the translocase of the outer membrane (TOM) together with the presequence translocase of the inner membrane (TIM23). After initial recognition by receptors of the TOM complex followed by transport across the outer membrane, the precursor emerges into the intermembrane space (IMS). Recognition of the presequence by Tim50 triggers rearrangements of the presequence translocase, priming it for inner membrane translocation. Subsequently, the precursor can be released into the membrane or translocated into the mitochondrial matrix aided by the import motor. This heat-shock protein 70 (Hsp70)-based motor drives precursor unfolding and translocation and is subject to dynamic remodelling. Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DNAJC19Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
Dnajc19Ratpresequence pathway of mitochondrial protein import  ISODNAJC19 (Homo sapiens) RGD 
Dnajc19Mousepresequence pathway of mitochondrial protein import  ISODNAJC19 (Homo sapiens) RGD 
GRPEL1Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
GRPEL2Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
Grpel1Ratpresequence pathway of mitochondrial protein import  ISOGRPEL1 (Homo sapiens) RGD 
Grpel1Mousepresequence pathway of mitochondrial protein import  ISOGRPEL1 (Homo sapiens) RGD 
Grpel2Ratpresequence pathway of mitochondrial protein import  ISOGRPEL2 (Homo sapiens) RGD 
Grpel2Mousepresequence pathway of mitochondrial protein import  ISOGRPEL2 (Homo sapiens) RGD 
HSPA9Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
Hspa9Ratpresequence pathway of mitochondrial protein import  ISOHSPA9 (Homo sapiens) RGD 
Hspa9Mousepresequence pathway of mitochondrial protein import  ISOHSPA9 (Homo sapiens) RGD 
PAM16Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
Pam16Mousepresequence pathway of mitochondrial protein import  ISOPAM16 (Homo sapiens) RGD 
Pam16Ratpresequence pathway of mitochondrial protein import  ISOPAM16 (Homo sapiens) RGD 
ROMO1Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
Romo1Ratpresequence pathway of mitochondrial protein import  ISOROMO1 (Homo sapiens) RGD 
Romo1Mousepresequence pathway of mitochondrial protein import  ISOROMO1 (Homo sapiens) RGD 
TIMM17AHumanpresequence pathway of mitochondrial protein import  TAS  RGD 
TIMM21Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TIMM23Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TIMM44Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TIMM50Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TOMM20Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TOMM22Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TOMM40Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TOMM5Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TOMM6Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TOMM7Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
TOMM70Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
Timm17aRatpresequence pathway of mitochondrial protein import  ISOTIMM17A (Homo sapiens) RGD 
Timm17aMousepresequence pathway of mitochondrial protein import  ISOTIMM17A (Homo sapiens) RGD 
Timm21Ratpresequence pathway of mitochondrial protein import  ISOTIMM21 (Homo sapiens) RGD 
Timm21Mousepresequence pathway of mitochondrial protein import  ISOTIMM21 (Homo sapiens) RGD 
Timm23Ratpresequence pathway of mitochondrial protein import  ISOTIMM23 (Homo sapiens) RGD 
Timm23Mousepresequence pathway of mitochondrial protein import  ISOTIMM23 (Homo sapiens) RGD 
Timm44Ratpresequence pathway of mitochondrial protein import  ISOTIMM44 (Homo sapiens) RGD 
Timm44Mousepresequence pathway of mitochondrial protein import  ISOTIMM44 (Homo sapiens) RGD 
Timm50Ratpresequence pathway of mitochondrial protein import  ISOTIMM50 (Homo sapiens) RGD 
Timm50Mousepresequence pathway of mitochondrial protein import  ISOTIMM50 (Homo sapiens) RGD 
Tomm20Ratpresequence pathway of mitochondrial protein import  ISOTOMM20 (Homo sapiens) RGD 
Tomm20Mousepresequence pathway of mitochondrial protein import  ISOTOMM20 (Homo sapiens) RGD 
Tomm22Ratpresequence pathway of mitochondrial protein import  ISOTOMM22 (Homo sapiens) RGD 
Tomm22Mousepresequence pathway of mitochondrial protein import  ISOTOMM22 (Homo sapiens) RGD 
Tomm40Ratpresequence pathway of mitochondrial protein import  ISOTOMM40 (Homo sapiens) RGD 
Tomm40Mousepresequence pathway of mitochondrial protein import  ISOTOMM40 (Homo sapiens) RGD 
Tomm5Ratpresequence pathway of mitochondrial protein import  ISOTOMM5 (Homo sapiens) RGD 
Tomm5Mousepresequence pathway of mitochondrial protein import  ISOTOMM5 (Homo sapiens) RGD 
Tomm6Ratpresequence pathway of mitochondrial protein import  ISOTOMM6 (Homo sapiens) RGD 
Tomm6Mousepresequence pathway of mitochondrial protein import  ISOTOMM6 (Homo sapiens) RGD 
Tomm7Mousepresequence pathway of mitochondrial protein import  ISOTOMM7 (Homo sapiens) RGD 
Tomm7Ratpresequence pathway of mitochondrial protein import  ISOTOMM7 (Homo sapiens) RGD 
Tomm70Ratpresequence pathway of mitochondrial protein import  ISOTOMM70 (Homo sapiens) RGD 
Tomm70aMousepresequence pathway of mitochondrial protein import  ISOTOMM70 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Dnajc19  (DnaJ heat shock protein family (Hsp40) member C19)
Grpel1  (GrpE-like 1, mitochondrial)
Grpel2  (GrpE-like 2, mitochondrial)
Hspa9  (heat shock protein family A (Hsp70) member 9)
Pam16  (presequence translocase associated motor 16)
Romo1  (reactive oxygen species modulator 1)
Timm17a  (translocase of inner mitochondrial membrane 17A)
Timm21  (translocase of inner mitochondrial membrane 21)
Timm23  (translocase of inner mitochondrial membrane 23)
Timm44  (translocase of inner mitochondrial membrane 44)
Timm50  (translocase of inner mitochondrial membrane 50)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70  (translocase of outer mitochondrial membrane 70)

Genes (Mus musculus)
Dnajc19  (DnaJ heat shock protein family (Hsp40) member C19)
Grpel1  (GrpE-like 1, mitochondrial)
Grpel2  (GrpE-like 2, mitochondrial)
Hspa9  (heat shock protein 9)
Pam16  (presequence translocase-asssociated motor 16)
Romo1  (reactive oxygen species modulator 1)
Timm17a  (translocase of inner mitochondrial membrane 17a)
Timm21  (translocase of inner mitochondrial membrane 21)
Timm23  (translocase of inner mitochondrial membrane 23)
Timm44  (translocase of inner mitochondrial membrane 44)
Timm50  (translocase of inner mitochondrial membrane 50)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70a  (translocase of outer mitochondrial membrane 70A)

Genes (Homo sapiens)
DNAJC19  (DnaJ heat shock protein family (Hsp40) member C19)
GRPEL1  (GrpE like 1, mitochondrial)
GRPEL2  (GrpE like 2, mitochondrial)
HSPA9  (heat shock protein family A (Hsp70) member 9)
PAM16  (presequence translocase associated motor 16)
ROMO1  (reactive oxygen species modulator 1)
TIMM17A  (translocase of inner mitochondrial membrane 17A)
TIMM21  (translocase of inner mitochondrial membrane 21)
TIMM23  (translocase of inner mitochondrial membrane 23)
TIMM44  (translocase of inner mitochondrial membrane 44)
TIMM50  (translocase of inner mitochondrial membrane 50)
TOMM20  (translocase of outer mitochondrial membrane 20)
TOMM22  (translocase of outer mitochondrial membrane 22)
TOMM40  (translocase of outer mitochondrial membrane 40)
TOMM5  (translocase of outer mitochondrial membrane 5)
TOMM6  (translocase of outer mitochondrial membrane 6)
TOMM7  (translocase of outer mitochondrial membrane 7)
TOMM70  (translocase of outer mitochondrial membrane 70)


Additional Information