RGD Reference Report - Cytoplasmic dynein. - Rat Genome Database

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Cytoplasmic dynein.

Authors: Allan, Victoria J 
Citation: Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
RGD ID: 10402142
Pubmed: PMID:21936784   (View Abstract at PubMed)
DOI: DOI:10.1042/BST0391169   (Journal Full-text)

The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's mechanochemistry, how it is regulated and how it binds to such a plethora of cargoes. The importance of a number of accessory factors in these processes is discussed.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DYNC1H1Humanmitochondria transport pathway  TAS  RGD 
DYNC1I1Humanmitochondria transport pathway  TAS  RGD 
DYNC1I2Humanmitochondria transport pathway  TAS  RGD 
DYNC1LI1Humanmitochondria transport pathway  TAS  RGD 
DYNC1LI2Humanmitochondria transport pathway  TAS  RGD 
DYNLL1Humanmitochondria transport pathway  TAS  RGD 
DYNLL2Humanmitochondria transport pathway  TAS  RGD 
DYNLRB1Humanmitochondria transport pathway  TAS  RGD 
DYNLRB2Humanmitochondria transport pathway  TAS  RGD 
DYNLT1Humanmitochondria transport pathway  TAS  RGD 
DYNLT3Humanmitochondria transport pathway  TAS  RGD 
Dync1h1Ratmitochondria transport pathway  ISODYNC1H1 (Homo sapiens) RGD 
Dync1h1Mousemitochondria transport pathway  ISODYNC1H1 (Homo sapiens) RGD 
Dync1i1Ratmitochondria transport pathway  ISODYNC1I1 (Homo sapiens) RGD 
Dync1i1Mousemitochondria transport pathway  ISODYNC1I1 (Homo sapiens) RGD 
Dync1i2Ratmitochondria transport pathway  ISODYNC1I2 (Homo sapiens) RGD 
Dync1i2Mousemitochondria transport pathway  ISODYNC1I2 (Homo sapiens) RGD 
Dync1li1Ratmitochondria transport pathway  ISODYNC1LI1 (Homo sapiens) RGD 
Dync1li1Mousemitochondria transport pathway  ISODYNC1LI1 (Homo sapiens) RGD 
Dync1li2Ratmitochondria transport pathway  ISODYNC1LI2 (Homo sapiens) RGD 
Dync1li2Mousemitochondria transport pathway  ISODYNC1LI2 (Homo sapiens) RGD 
Dynll1Ratmitochondria transport pathway  ISODYNLL1 (Homo sapiens) RGD 
Dynll1Mousemitochondria transport pathway  ISODYNLL1 (Homo sapiens) RGD 
Dynll2Ratmitochondria transport pathway  ISODYNLL2 (Homo sapiens) RGD 
Dynll2Mousemitochondria transport pathway  ISODYNLL2 (Homo sapiens) RGD 
Dynlrb1Ratmitochondria transport pathway  ISODYNLRB1 (Homo sapiens) RGD 
Dynlrb1Mousemitochondria transport pathway  ISODYNLRB1 (Homo sapiens) RGD 
Dynlrb2Ratmitochondria transport pathway  ISODYNLRB2 (Homo sapiens) RGD 
Dynlrb2Mousemitochondria transport pathway  ISODYNLRB2 (Homo sapiens) RGD 
Dynlt1Ratmitochondria transport pathway  ISODYNLT1 (Homo sapiens) RGD 
Dynlt3Ratmitochondria transport pathway  ISODYNLT3 (Homo sapiens) RGD 
Dynlt3Mousemitochondria transport pathway  ISODYNLT3 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Dync1h1  (dynein cytoplasmic 1 heavy chain 1)
Dync1i1  (dynein cytoplasmic 1 intermediate chain 1)
Dync1i2  (dynein cytoplasmic 1 intermediate chain 2)
Dync1li1  (dynein cytoplasmic 1 light intermediate chain 1)
Dync1li2  (dynein, cytoplasmic 1 light intermediate chain 2)
Dynll1  (dynein light chain LC8-type 1)
Dynll2  (dynein light chain LC8-type 2)
Dynlrb1  (dynein light chain roadblock-type 1)
Dynlrb2  (dynein light chain roadblock-type 2)
Dynlt1  (dynein light chain Tctex-type 1)
Dynlt3  (dynein light chain Tctex-type 3)

Genes (Mus musculus)
Dync1h1  (dynein cytoplasmic 1 heavy chain 1)
Dync1i1  (dynein cytoplasmic 1 intermediate chain 1)
Dync1i2  (dynein cytoplasmic 1 intermediate chain 2)
Dync1li1  (dynein cytoplasmic 1 light intermediate chain 1)
Dync1li2  (dynein, cytoplasmic 1 light intermediate chain 2)
Dynll1  (dynein light chain LC8-type 1)
Dynll2  (dynein light chain LC8-type 2)
Dynlrb1  (dynein light chain roadblock-type 1)
Dynlrb2  (dynein light chain roadblock-type 2)
Dynlt3  (dynein light chain Tctex-type 3)

Genes (Homo sapiens)
DYNC1H1  (dynein cytoplasmic 1 heavy chain 1)
DYNC1I1  (dynein cytoplasmic 1 intermediate chain 1)
DYNC1I2  (dynein cytoplasmic 1 intermediate chain 2)
DYNC1LI1  (dynein cytoplasmic 1 light intermediate chain 1)
DYNC1LI2  (dynein cytoplasmic 1 light intermediate chain 2)
DYNLL1  (dynein light chain LC8-type 1)
DYNLL2  (dynein light chain LC8-type 2)
DYNLRB1  (dynein light chain roadblock-type 1)
DYNLRB2  (dynein light chain roadblock-type 2)
DYNLT1  (dynein light chain Tctex-type 1)
DYNLT3  (dynein light chain Tctex-type 3)


Additional Information