RGD Reference Report - Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons. - Rat Genome Database

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Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons.

Authors: Ivanov, A  Esclapez, M  Pellegrino, C  Shirao, T  Ferhat, L 
Citation: Ivanov A, etal., J Cell Sci. 2009 Feb 15;122(Pt 4):524-34. doi: 10.1242/jcs.033464. Epub 2009 Jan 27.
RGD ID: 10398809
Pubmed: PMID:19174472   (View Abstract at PubMed)
DOI: DOI:10.1242/jcs.033464   (Journal Full-text)

Drebrin A, one of the most abundant neuron-specific F-actin-binding proteins, is found exclusively in dendrites and is particularly concentrated in dendritic spines receiving excitatory inputs. We investigated the role of drebrin A in synaptic transmission and found that overexpression of drebrin A augmented the glutamatergic synaptic transmission, probably through an increase of active synaptic site density. Interestingly, overexpression of drebrin A also affected the frequency, amplitude and kinetics of miniature inhibitory postsynaptic currents (mIPSCs), despite the fact that GABAergic synapse density and transmission efficacy were not modified. Downregulation of drebrin A led to a decrease of both glutamatergic and GABAergic synaptic activity. In heterologous cells, drebrin A reorganized and stabilized F-actin and these effects were mediated by its actin-binding domain. Thus, drebrin A might regulate dendritic spine morphology via regulation of actin cytoskeleton remodeling and dynamics. Our data demonstrate for the first time that drebrin A modulates glutamatergic and GABAergic synaptic activities.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Dbn1Ratmodulation of inhibitory postsynaptic potential  IMP  RGD 
Dbn1Ratpositive regulation of dendritic spine morphogenesis  IMP  RGD 
Dbn1Ratpositive regulation of excitatory postsynaptic potential  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dbn1  (drebrin 1)


Additional Information