RGD Reference Report - Down-regulation of cell-surface CD4 co-receptor expression and modulation of experimental allergic encephalomyelitis. - Rat Genome Database

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Down-regulation of cell-surface CD4 co-receptor expression and modulation of experimental allergic encephalomyelitis.

Authors: Fiori, P  Ristori, G  Cacciani, A  Buttinelli, C  Falcone, M  Di Giovanni, S  Montesperelli, C  Pozzilli, C  Salvetti, M 
Citation: Fiori P, etal., Int Immunol. 1997 Apr;9(4):541-5.
RGD ID: 10058963
Pubmed: PMID:9138014   (View Abstract at PubMed)

Pre-immunization with autoantigens confers resistance in experimental models of autoimmune diseases. Since non-self molecules can also be protective, it is conceivable that part of the effect rests on a non-specific attenuation of the immune response. This study is aimed at identifying mechanisms by which pre-immunization with a moiety suspended in incomplete Freund's adjuvant (IFA) protects from experimental allergic encephalomyelitis (EAE). Lewis rats were immunized with each of either concanavalin A, lipopolysaccharide, bovine serum albumin, 70 or 65 kDa heat shock proteins, or myelin basic protein. All moieties were given in IFA 3 weeks prior to EAE induction. Serial cytofluorimetric monitoring of B cells and of the alpha beta TCR+, CD4+, CD8+, CD45high and CD45low cells was performed. IFN-gamma and IgG1 production was evaluated in parallel. All moieties were able to attenuate or abrogate the clinical signs of EAE. At day 4 and 10 after EAE induction, the surface expression of the CD4 molecule was down-regulated on T lymphocytes. This down-regulation was most evident in animals with the highest degree of clinical protection. By day 21 post-immunization, CD4 expression was restored. The same animals also showed an increase in the B cell percentage and Th2-related IgG1 production while IFN-gamma secretion was reduced. Pre-immunization with diverse antigens suspended in IFA confers resistance to EAE induction. The down-regulation of the CD4 co-receptor accompanied by events suggestive of an immune deviation may be a general mechanism that contributes to the protection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD4HumanExperimental Autoimmune Encephalomyelitis  ISOCd4 (Rattus norvegicus)protein:decreased expression:T lymphocyte:RGD 
Cd4RatExperimental Autoimmune Encephalomyelitis  IEP protein:decreased expression:T lymphocyte:RGD 
Cd4MouseExperimental Autoimmune Encephalomyelitis  ISOCd4 (Rattus norvegicus)protein:decreased expression:T lymphocyte:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd4  (Cd4 molecule)

Genes (Mus musculus)
Cd4  (CD4 antigen)

Genes (Homo sapiens)
CD4  (CD4 molecule)


Additional Information