RGD Reference Report - Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension. - Rat Genome Database

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Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension.

Authors: Redina, OE  Smolenskaya, SE  Maslova, LN  Markel, AL 
Citation: Redina OE, etal., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502.
RGD ID: 10053640
Pubmed: PMID:21029000   (View Abstract at PubMed)
DOI: DOI:10.3109/10641961003628502   (Journal Full-text)

The genetic background of the regulatory systems of the hypothalamic-pituitary-adrenal (HPA) axis in hypertension remains unclear. The inherited stress-induced arterial hypertension (ISIAH) and Wistar Albino Glaxo (WAG) normotensive rats were bred and their F(2) progeny were used in a quantitative trait loci (QTL) analysis to identify genomic regions for plasma basal and stress-induced corticosterone levels, and for absolute and relative adrenal gland weights. The significant loci were found for stress-induced corticosterone on chromosome 9 and for adrenal weight on chromosome 6. The results may help to identify the genes controlling the trait phenotypes in the ISIAH rats characterized by the enhanced responsiveness to stressful stimulation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Stress-Induced Hypertension  IAGP 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640; 10053640 RGD 

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Mammalian Phenotype


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Objects Annotated

QTLs
Gmadr2  (Adrenal mass QTL 2)
Gmadr3  (Adrenal mass QTL 3)
Gmadr4  (Adrenal mass QTL 4)
Gmadr5  (Adrenal mass QTL 5)
Gmadr6  (Adrenal mass QTL 6)
Gmadr7  (Adrenal mass QTL 7)
Scort23  (Serum corticosterone level QTL 23)
Scort24  (Serum corticosterone level QTL 24)
Scort25  (Serum corticosterone level QTL 25)
Scort26  (Serum corticosterone level QTL 26)
Scort27  (Serum corticosterone level QTL 27)
Scort28  (Serum corticosterone level QTL 28)
Srcrt6  (Stress Responsive Cort QTL 6)
Srcrt7  (Stress Responsive Cort QTL 7)
Srcrt8  (Stress Responsive Cort QTL 8)
Srcrt9  (Stress Responsive Cort QTL 9)

Strains
ISIAH  (Inherited stress-induced arterial hypertension)
WAG/Nov  (NA)

Objects referenced in this article
QTL Anxrr23 Anxiety related response QTL 23 Rattus norvegicus
QTL Anxrr4 Anxiety related response QTL 4 Rattus norvegicus
QTL Anxrr5 Anxiety related response QTL 5 Rattus norvegicus
QTL Anxrr8 Anxiety related response QTL 8 Rattus norvegicus
QTL Srcrt4 Stress Responsive Cort QTL 4 Rattus norvegicus
QTL Thshl1 Thyroid stimulating hormone level QTL 1 Rattus norvegicus
QTL Thshl2 Thyroid stimulating hormone level QTL 2 Rattus norvegicus

Additional Information