RGD Reference Report - The genetic control of blood pressure and body composition in rats with stress-sensitive hypertension. - Rat Genome Database

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The genetic control of blood pressure and body composition in rats with stress-sensitive hypertension.

Authors: Redina, OE  Smolenskaya, SE  Maslova, LN  Markel, AL 
Citation: Redina OE, etal., Clin Exp Hypertens. 2013;35(7):484-95. doi: 10.3109/10641963.2012.758274. Epub 2013 Jan 9.
RGD ID: 10053637
Pubmed: PMID:23302051   (View Abstract at PubMed)
DOI: DOI:10.3109/10641963.2012.758274   (Journal Full-text)

The genetic basis of the stress-sensitive arterial hypertension was investigated using the quantitative trait loci (QTL) approach. Two groups of F2 (inherited stress-induced arterial hypertension [ISIAH] x Wistar albino Glaxo [WAG]) hybrid males of different age (3-4 months old and 6 months old) were tested for blood pressure at rest and stressed conditions and for body composition traits. Several novel loci for the traits were determined. Some loci for blood pressure and organ weight were mapped to the same genetic region in rats of different age. The dynamic change of QTL effects in two rat groups of different age might reflect the process of stress-sensitive hypertension development.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp377  (Blood pressure QTL 377)
Bp378  (Blood pressure QTL 378)
Bw173  (Body weight QTL 173)
Bw174  (Body weight QTL 174)
Kidm44  (Kidney mass QTL 44)
Kidm45  (Kidney mass QTL 45)
Kidm46  (Kidney mass QTL 46)
Kidm47  (Kidney mass QTL 47)

Strains
ISIAH  (Inherited stress-induced arterial hypertension)
WAG/Nov  (NA)


Additional Information