RGD Reference Report - Formation of heteromeric Kv2 channels in mammalian brain neurons. - Rat Genome Database

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Formation of heteromeric Kv2 channels in mammalian brain neurons.

Authors: Kihira, Y  Hermanstyne, TO  Misonou, H 
Citation: Kihira Y, etal., J Biol Chem. 2010 May 14;285(20):15048-55. doi: 10.1074/jbc.M109.074260. Epub 2010 Mar 4.
RGD ID: 10047337
Pubmed: PMID:20202934   (View Abstract at PubMed)
PMCID: PMC2865335   (View Article at PubMed Central)
DOI: DOI:10.1074/jbc.M109.074260   (Journal Full-text)

The formation of heteromeric tetramers is a common feature of voltage-gated potassium (Kv) channels. This results in the generation of a variety of tetrameric Kv channels that exhibit distinct biophysical and biochemical characteristics. Kv2 delayed rectifier channels are, however, unique exceptions. It has been previously shown that mammalian Kv2.1 and Kv2.2 are localized in distinct domains of neuronal membranes and are not capable of forming heteromeric channels with each other (Hwang, P. M., Glatt, C. E., Bredt, D. S., Yellen, G., and Snyder, S. H. (1992) Neuron 8, 473-481). In this study, we report a novel form of rat Kv2.2, Kv2.2(long), which has not been previously recognized. Our data indicate that Kv2.2(long) is the predominant form of Kv2.2 expressed in cortical pyramidal neurons. In contrast to the previous findings, we also found that rat Kv2.1 and Kv2.2(long) are colocalized in the somata and proximal dendrites of cortical pyramidal neurons and are capable of forming functional heteromeric delayed rectifier channels. Our results suggest that the delayed rectifier currents, which regulate action potential firing, are encoded by heteromeric Kv2 channels in cortical neurons.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnb1Ratpotassium ion transmembrane transport involved_inIDA PMID:20202934UniProt 
Kcnb2Ratpotassium ion transmembrane transport involved_inIDA PMID:20202934UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnb1Ratdendrite located_inIDA PMID:20202934UniProt 
Kcnb2Ratdendrite located_inIDA PMID:20202934UniProt 
Kcnb1Ratneuronal cell body membrane located_inIDA PMID:20202934UniProt 
Kcnb2Ratneuronal cell body membrane located_inIDA PMID:20202934UniProt 
Kcnb1Ratvoltage-gated potassium channel complex part_ofIDA PMID:20202934UniProt 
Kcnb2Ratvoltage-gated potassium channel complex part_ofIDA PMID:20202934UniProt 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Kcnb1  (potassium voltage-gated channel subfamily B member 1)
Kcnb2  (potassium voltage-gated channel subfamily B member 2)


Additional Information