RGD Reference Report - Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. - Rat Genome Database

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Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current.

Authors: Post, MA  Kirsch, GE  Brown, AM 
Citation: Post MA, etal., FEBS Lett. 1996 Dec 9;399(1-2):177-82.
RGD ID: 10047188
Pubmed: PMID:8980147   (View Abstract at PubMed)

Heteromultimer formation between Kv potassium channel subfamilies with the production of a novel current is reported for the first time. Protein-protein interactions between Kv2.1 and electrically silent Kv6.1 alpha-subunits were detected using two microelectrode voltage clamp and yeast two-hybrid measurements. Amino terminal portions of Kv6.1 were unable to form homomultimers but interacted specifically with amino termini of Kv2.1. Xenopus oocytes co-injected with Kv6.1 and Kv2.1 cRNAs exhibited a novel current with decreased rates of deactivation, decreased sensitivity to TEA block, and a hyperpolarizing shift of the half maximal activation potential when compared to Kv2.1. Our results indicate that Kv channel subfamilies can form heteromultimeric channels and, for the first time, suggest a possible functional role for the Kv6 subfamily.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnb1Ratpotassium ion transmembrane transport involved_inIDA PMID:8980147UniProt 
Kcng1Ratregulation of potassium ion transmembrane transport involved_inIDA PMID:8980147UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnb1Ratvoltage-gated potassium channel complex part_ofIDA PMID:8980147UniProt 
Kcng1Ratvoltage-gated potassium channel complex part_ofIDA PMID:8980147UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnb1Ratdelayed rectifier potassium channel activity NOT|enablesIDA PMID:8980147UniProt 
Kcng1Ratpotassium channel regulator activity enablesIDA PMID:8980147UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcnb1  (potassium voltage-gated channel subfamily B member 1)
Kcng1  (potassium voltage-gated channel modifier subfamily G member 1)


Additional Information