RGD Reference Report - An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin. - Rat Genome Database

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An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin.

Authors: Robin, MM  Palfreyman, MG  Zraika, MM  Schechter, PJ 
Citation: Robin MM, etal., Eur J Pharmacol. 1980 Apr 4;62(4):319-27.
RGD ID: 10047091
Pubmed: PMID:6445277   (View Abstract at PubMed)

Unilateral intrastriatal injection of various substances induces a characteristic dyskinetic syndrome in rats. These substances include picrotoxin as well as a series of irreversible GABA-transaminase inhibitors. Using the degree of enzyme inhibition in various brain areas as a measure of drug distribution following intrastriatal administration of gamma-acetylenic GABA and gamma-vinyl GABA, there was found considerable retrodiffusion via the needle tract to the overlying cortex. Topical application of gamma-acetylenic GABA and gamma-vinyl GABA to the cortical surface overlying the striatum produced a high incidence of identical dyskinesias without any evidence of diffusion of drugs to the striatum. The cortically induced movements could be duplicated by picrotoxin application to a defined cortical area. These findings suggest that interference with gabaergic function in the striatum is not necessary for the production of the dyskinetic syndrome and that this syndrome may be a cortically induced phenomenon.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Abat  (4-aminobutyrate aminotransferase)
Glul  (glutamate-ammonia ligase)

Genes (Mus musculus)
Abat  (4-aminobutyrate aminotransferase)
Glul  (glutamate-ammonia ligase)

Genes (Homo sapiens)
ABAT  (4-aminobutyrate aminotransferase)
GLUL  (glutamate-ammonia ligase)


Additional Information