RGD Reference Report - The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. - Rat Genome Database

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The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression.

Authors: Giorgi, C  Yeo, GW  Stone, ME  Katz, DB  Burge, C  Turrigiano, G  Moore, MJ 
Citation: Giorgi C, etal., Cell. 2007 Jul 13;130(1):179-91.
RGD ID: 10044262
Pubmed: PMID:17632064   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cell.2007.05.028   (Journal Full-text)

Proper neuronal function and several forms of synaptic plasticity are highly dependent on precise control of mRNA translation, particularly in dendrites. We find that eIF4AIII, a core exon junction complex (EJC) component loaded onto mRNAs by pre-mRNA splicing, is associated with neuronal mRNA granules and dendritic mRNAs. eIF4AIII knockdown markedly increases both synaptic strength and GLUR1 AMPA receptor abundance at synapses. eIF4AIII depletion also increases ARC, a protein required for maintenance of long-term potentiation; arc mRNA, one of the most abundant in dendrites, is a natural target for nonsense-mediated decay (NMD). Numerous new NMD candidates, some with potential to affect synaptic activity, were also identified computationally. Two models are presented for how translation-dependent decay pathways such as NMD might advantageously function as critical brakes for protein synthesis in cells such as neurons that are highly dependent on spatially and temporally restricted protein expression.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Eif4a3Ratdendrite  IDA  RGD 
Eif4a3Ratglutamatergic synapse is_active_inIDA PMID:17632064SynGO 
Eif4a3Ratglutamatergic synapse is_active_inIMP PMID:17632064SynGO 
Eif4a3Ratneuronal cell body  IDA  RGD 
Eif4a3Ratribonucleoprotein complex  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Eif4a3Ratribonucleoprotein complex binding  IDA Fmr1RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eif4a3  (eukaryotic translation initiation factor 4A3)


Additional Information