RGD Reference Report - The major histocompatibility complex genes are associated with basal pain sensitivity differences between Dark-Agouti and novel congenic DA.1U rats. - Rat Genome Database

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The major histocompatibility complex genes are associated with basal pain sensitivity differences between Dark-Agouti and novel congenic DA.1U rats.

Authors: Guo, Y  Yao, F  Lu, S  Cao, DY  Reed, WR  Zhao, Y 
Citation: Guo Y, etal., Life Sci. 2010 Jun 19;86(25-26):972-8. doi: 10.1016/j.lfs.2010.05.006. Epub 2010 May 13.
RGD ID: 10002747
Pubmed: PMID:20471989   (View Abstract at PubMed)
DOI: DOI:10.1016/j.lfs.2010.05.006   (Journal Full-text)

AIMS: To investigate whether MHC genes are associated with basal pain sensitivity differences in Dark-Agouti (DA) rats and a novel congenic inbred DA.1U rats, whose genetic background is the same as DA rats except for major histocompatibility complex (MHC) genes. MAIN METHODS: Mechanical withdrawal threshold (MWT) and heat withdrawal latencies (HWL) were compared in the two rat strains to reflect basal pain sensitivity. Immunohistochemistry was used to observe the expression level of RT1B, representative of MHC class II DQ region, and the basal expression of phosphorylated cAMP response element-binding protein (pCREB) in the L4/L5 spinal cord in the two rat strains. KEY FINDINGS: The MWT and HWL of DA rats were significantly less than that of DA.1U rats. The expression level of pCREB in the L4/L5 spinal cord in DA rats was greater than that found in DA.1U rats. The expression level of RT1B in the spinal cord was greater in DA rats, which suggested MHC class II DQ region is likely involved in the differences in sensitivity to noxious mechanical and thermal stimulation between the two rat strains. SIGNIFICANCE: These results suggest MHC genes are associated with basal pain sensitivity, which may contribute to the identification of pain sensitivity and/or individually tailored pain treatment regimens.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DA.E3-(D20Rat47-AA858870)/RhdRatHyperalgesia susceptibilityIAGP compared to DA/ZtmRhdRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DA.E3-(D20Rat47-AA858870)/RhdRatincreased mechanical nociceptive threshold  IAGP  RGD 
DA.E3-(D20Rat47-AA858870)/RhdRatincreased thermal nociceptive threshold  IAGP  RGD 
Objects Annotated

Objects referenced in this article
Strain DA.E3-(D20Rat42-D20Rat49)/Rhd null Rattus norvegicus

Additional Information