Insglur4 QTL Report (Rattus norvegicus)

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QTL Registration

General

QTL: Insglur4 (Insulin/glucose ratio QTL 4) Rattus norvegicus

Symbol:

Insglur4

Name:

Insulin/glucose ratio QTL 4

RGD ID:

9590080

Previously known as:

insulin resistance

Trait:

blood insulin amount (VT:0001560)

Measurement Type:

calculated plasma insulin level (CMO:0002170)

LOD Score:

28.7

P Value:

0.001

Variance:

23.2

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	3,686,308 - 48,686,308	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	2	22,817,824 - 67,817,824	RGD_MAPPER_PIPELINE	Rnor5.0

Cross Type:

intercross

Strains Crossed:

F344/IcoCrlf LOU/NimrOlaHsd

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Insulin Resistance (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

insulin resistance (IAGP)

Experimental Data Annotations Click to see Annotation Detail View

Clinical Measurement

calculated plasma insulin level (IDA)

Experimental Condition

control condition (IDA)

Measurement Method

radioimmunoassay (IDA)

Vertebrate Trait

blood insulin amount (IDA)

Rat Strain

F344/IcoCrlf (IEA)

LOU/NimrOlaHsd (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Quantitative Trait Loci Influencing Abdominal Fat Deposition and Functional Variability of the HPA Axis in the Rat.	Marissal-Arvy N, etal., Horm Metab Res. 2014 Jul 8.

Region

Markers in Region

The following Markers overlap with this region.

RGD ID

Symbol

Expected Size

Chr

Start

Stop

Species

Match

Position Markers

Peak: (D2Rat124)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	26,917,817 - 26,918,153 (+)	MAPPER
mRatBN7.2	8	116,760,064 - 116,760,124 (-)	MAPPER
mRatBN7.2	2	26,917,948 - 26,918,153 (+)	MAPPER
Rnor_6.0	2	26,186,318 - 26,186,520	NCBI
Rnor_6.0	2	26,186,097 - 26,186,520	NCBI
Rnor_5.0	2	45,317,834 - 45,318,036	UniSTS
Rnor_5.0	2	45,317,613 - 45,318,036	UniSTS
Celera	2	22,980,838 - 22,981,040	UniSTS
RH 3.4 Map	2	13.3	RGD
RH 3.4 Map	2	13.3	UniSTS
RH 2.0 Map	2	78.1	RGD
SHRSP x BN Map	2	7.2098	RGD
FHH x ACI Map	2	12.9999	RGD

Additional Information

RGD Curation Notes

Note Type	Note	Reference
qtl_general	confidence interval 23.0-24.7 Mb	8694157
qtl_general	number of animals used: 93 F₂ males and 94 F₂ females	8694157
qtl_general	measurement method: at the end of the HPA axis function experiment, animals were fasted overnight, blood samples collected (T0), 2 min later rats were injected with 4IU/kg insulin and blood samples taken T0+30 min; insulin resistance estimated as the percentage of decrease in glycemia	8694157
qtl_general	software package used: MultiQTL software	8694157
qtl_general	an additional peak at D2Mit11 with confidence interval 170.9-188.8 Mb was observed	8694157

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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QTL: Insglur4 (Insulin/glucose ratio QTL 4) Rattus norvegicus

Mammalian Phenotype