Mcs34 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Mcs34 (Mammary carcinoma susceptibility QTL 34) Rattus norvegicus

Symbol: Mcs34
Name: Mammary carcinoma susceptibility QTL 34
RGD ID: 7794793
Previously known as: Chr18-Mts-4; Mts-4
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor incidence/prevalence measurement   (CMO:0000946)    
LOD Score: 1.54
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81865,635,567 - 85,897,775RGD_MAPPER_PIPELINE
Rnor_5.01864,771,076 - 83,650,204RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41866,439,387 - 87,265,094RGD_MAPPER_PIPELINERGSC3.4
Cross Type: intercross
Strains Crossed: SR/JrHsd SS/JrHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Smad2 is a candidate Gene for Mcs34

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
SR/JrHsd  (IEA)
SS/JrHsd  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Multiple susceptibility loci for radiation-induced mammary tumorigenesis in F2-intercross rats. Herrera VL, etal., PLoS One. 2013;8(8):e72143. doi: 10.1371/journal.pone.0072143. eCollection 2013.

Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (D18Rat127)
Rat AssemblyChrPosition (strand)Source
GRCr81865,635,567 - 65,635,940 (+)Marker Load Pipeline
Rnor_5.01864,771,077 - 64,771,334NCBI
Rnor_5.01864,771,076 - 64,771,334NCBI
RGSC_v3.41866,439,387 - 66,439,760RGD
RGSC_v3.41866,439,388 - 66,439,760UniSTS
RGSC_v3.11866,512,558 - 66,513,020RGD
Celera1861,445,741 - 61,446,112UniSTS
SHRSP x BN Map1837.6799RGD
SHRSP x BN Map1837.6799UniSTS
FHH x ACI Map1843.1RGD
Peak: (D18Rat80)
Rat AssemblyChrPosition (strand)Source
GRCr81875,766,612 - 75,766,730 (+)Marker Load Pipeline
Rnor_5.01872,252,662 - 72,252,781NCBI
Rnor_5.016593,392 - 593,510NCBI
Rnor_5.01876,168,501 - 76,168,619NCBI
Rnor_5.01872,252,662 - 72,252,780NCBI
Rnor_5.016593,391 - 593,510NCBI
Rnor_5.01876,168,500 - 76,168,619NCBI
RGSC_v3.41876,935,779 - 76,935,896UniSTS
RGSC_v3.41876,935,778 - 76,935,896RGD
RGSC_v3.11877,009,051 - 77,009,169RGD
Celera1872,154,615 - 72,154,732UniSTS
SHRSP x BN Map1847.8399RGD
SHRSP x BN Map1847.8399UniSTS


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross 7794780
qtl_general spans Chr18:66-86 Mbp 7794780
qtl_general inducing agent: one dose of 400 r 127Cs-radiation 7794780
qtl_general measuring method: mammary tumor was induced at 40 days of age by whole body radiation; animals were sacrificed when tumors were 3 cm in diameter or at 12 months of age; tumor latency and tumor burden index was calculated 7794780
qtl_general number of animals: 12 each of SR/JrHsd and SS/JrHsd; 150 F2 sex of animals: females 7794780
qtl_general software used: Map Manager QTXb19 7794780
qtl_general SR/JrHsd exhibit decrease tumor latency and increase tumor burden index compared to SS/JrHsd 7794780