Bp373 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp373 (Blood pressure QTL 373) Rattus norvegicus

Symbol: Bp373
Name: Blood pressure QTL 373
RGD ID: 7794743
Previously known as: QTL2
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: Not Available
P Value: 0.0058
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25112,175,546 - 116,047,089RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05116,151,740 - 120,258,073RGD_MAPPER_PIPELINERnor6.0
Cross Type: Not Available
Strains Crossed: SS.LEW-(D5Mco42-D5Mco47)/2Mco 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Raver2 is a candidate Gene for Bp373

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Isolation and high-throughput sequencing of two closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains. Pillai R, etal., Physiol Genomics. 2013 Aug 15;45(16):729-36. doi: 10.1152/physiolgenomics.00077.2013. Epub 2013 Jun 11.
Related QTLs

Related QTL Description Reference
Bp372 interacts with RGD:7495753
Bp157 sub_region RGD:7495753


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
7502785LOC102553524uncharacterized LOC1025535245112230510112246625Rat
41175373LOC120103115uncharacterized LOC1201031155112244680112248682Rat
41107926LOC120103114uncharacterized LOC1201031145112416267112442856Rat
3170Nfianuclear factor I/A5112436655112781878Rat
11413852LOC108351005uncharacterized LOC1083510055112797944112805529Rat
2318487Rps18l5ribosomal protein S18-like 55112997100112997655Rat
1305442Tm2d1TM2 domain containing 15113020793113062134Rat
1565362PatjPATJ, crumbs cell polarity complex component5113061985113364807Rat
1595093L1td1LINE-1 type transposase domain containing 15113373193113386088Rat
1307635Kank4KN motif and ankyrin repeat domains 45113401491113465526Rat
41215575Usp15-ps2ubiquitin specific peptidase 15, pseudogene 25113559958113563874Rat
1306461Usp1ubiquitin specific peptidase 15113587564113598934Rat
1309790Dock7dedicator of cytokinesis 75113599371113782871Rat
1564505Angptl3angiopoietin-like 35113703007113710044Rat
40981943Rpl15-ps14ribosomal protein L15, pseudogene 145113792289113793252Rat
1598323Atg4cautophagy related 4C, cysteine peptidase5113867218113935534Rat
7514994LOC102556219uncharacterized LOC1025562195113969322113977654Rat
2318140Tomm7-ps2translocase of outer mitochondrial membrane 7, pseudogene 25114217624114218000Rat
1591391Nsmce1-ps1NSE1 homolog, SMC5-SMC6 complex component, pseudogene 15114291743114292689Rat
7645046LOC102556374uncharacterized LOC1025563745114332364114334002Rat
621715Foxd3forkhead box D35114335084114337450Rat
1308815Alg6ALG6, alpha-1,3-glucosyltransferase5114404972114454440Rat
1310044Itgb3bpintegrin subunit beta 3 binding protein5114460217114525538Rat
1561825Efcab7EF-hand calcium binding domain 75114525403114576130Rat
3316Pgm1phosphoglucomutase 15114595298114654728Rat
1559469Ror1receptor tyrosine kinase-like orphan receptor 15114744311115088155Rat
41197686Rnu6-233RNA, U6 small nuclear 2335115066080115066186Rat
41373478LOC120103197U6 spliceosomal RNA5115097451115097553Rat
1565480Ube2uubiquitin conjugating enzyme E2 U5115118234115187296Rat
1310770Cachd1cache domain containing 15115411833115637312Rat
1307610Raver2ribonucleoprotein, PTB-binding 25115700985115780465Rat
69056Jak1Janus kinase 15115780248115888841Rat
41340414LOC120103217U6 spliceosomal RNA5115816834115816936Rat
41350661LOC120103254small nucleolar RNA SNORA705115961775115961902Rat
41367836LOC120102934uncharacterized LOC1201029345115963226115977411Rat
2325348Mir101amicroRNA 101a5115966332115966406Rat
41361854Rpl9-ps16ribosomal protein L9, pseudogene 165115982278115982849Rat
2078Ak4adenylate kinase 45116039222116099064Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
11090D5Rhm21695114659557114659726Ratregion
35306D5Rat261545113558156113558310Ratregion
37200D5Rat782375114305693114305938Ratregion
37644D5Rat1152035112419535112419733Ratregion
36687D5Rat251745113060909113061097Ratregion
38156D5Rat1012115116021949116022166Ratregion
39248D5Rat722265114973303114973531Ratregion
42751D5Rat2322335114305693114305935Ratregion
41678D5Rat1971815112426055112426208Ratregion
43944D5Wox182735112450727112450995Ratregion
43945D5Got391875112936348112936533Ratregion
43948D5Got381475112393083112393230Ratregion
43949D5Got1331865113505602113505790Ratregion
43951D5Got371545114165957114166111Ratregion
69547D5Uwm301695115439450115439638Ratregion
1629468D5Got1323005115813691115813986Ratregion
1629713D5Got2441445113426023113426167Ratregion
1640622D5Got3112495114773489114773738Ratregion
7794807D5Mco422275116047089116047316Ratregion
7794818D5Mco472185112175328112175546Ratregion
7206256Olfm1845113761244113761328Ratregion
5028681RH80440895112513923112514012Ratregion
5026198RH1312932145113710616113710834Ratregion
5034289RH1420791995113362916113363115Ratregion
5028927RH1428512445113046670113046914Ratregion
5029021RH1432161085113364282113364390Ratregion
5031802AU0470991945114075177114075371Ratregion
5029379RH1445711595112416310112416469Ratregion
5035154AI0102541725115637807115637978Ratregion
5027073D1S34192605112776883112777140Ratregion
5029643BF3865221515113597258113597409Ratregion
5029665BF3867891955114594795114594990Ratregion
5030817BE1203321555115420521115420676Ratregion
5056903RH1446471545114927739114927893Ratregion
5057404AA9631301995112781625112781824Ratregion
5055315RH1437301525112570624112570776Ratregion
5057944BF3863831995113615563113615761Ratregion
5058580BI2908941185114468360114468478Ratregion
5058958BE1026141775112428800112428977Ratregion
5052997RH1423941805113598233113598414Ratregion
5050786RH1342571955112337803112337996Ratregion
5052825RH1422952005114627194114627782Ratregion
5054731RH1433931505115964001115964151Ratregion
5041158RH1286952125115780301115780513Ratregion
5044270RH1305062105113401660113401870Ratregion
5044706RH1307571905114217691114217882Ratregion
5047142RH1321571875113020904113021091Ratregion
5048344RH1328492085115767778115767986Ratregion
5042462RH1294491885113703534113704516Ratregion
5049608RH1335781825113977345113977527Ratregion
5042358RH1293881855115778575115778760Ratregion
5042876RH1296971835113598647113598830Ratregion
5075916RH1388711485115763615115763763Ratregion
5080712RH1417382095114654451114654660Ratregion
5065040BF4055471595115575933115576092Ratregion
5067014AU0480162195114295504114295725Ratregion
5062610BE1069441575113596852113597009Ratregion
5062546BI2889681895112466595112466784Ratregion
5063096BE1071211545112781235112781389Ratregion
5063226BE1073781665113599438113599604Ratregion
5061656BF3969991475114332400114332547Ratregion
5086907BE1074621625113385860113386022Ratregion
5086979AI2364572015115963802115964002Ratregion
5086445BE1063121555115636886115637041Ratregion
5085012AI0095531155112230744112230859Ratregion
5088469AU0485881695115621390115621559Ratregion
5090499AU0497861355113246624113246759Ratregion
5085922BM3851741565112414467112414623Ratregion
5504859ha253105114606869114607662Ratregion
5499843UniSTS:2349692875113335953113336240Ratregion
5499845UniSTS:2349673385113385613113385951Ratregion
5500515RH135495975113703231113703328Ratregion
5506509AL0093641495113751250113751399Ratregion
Position Markers

Flank 1: (D5Mco42)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,047,089 - 116,047,316 (+)MAPPER
Rnor_6.05120,258,073 - 120,258,299RGD
Cytogenetic Map5 RGD
Flank 2: (D5Mco47)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25112,175,328 - 112,175,546 (+)MAPPER
Rnor_6.05116,151,523 - 116,151,740RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
7794743Bp373Blood pressure QTL 3730.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5112175546116047089Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general measurement method:2% NaCl diet was given to 42 days old rats for 24 days; systolic blood pressure was measured on the same 4 days between 7 am and 12 pm by the tail-cuff method and the values averaged for 3-4 consistent readings. C40 radiotelemetry transmitters were surgically implanted and blood pressure recorded for 3 days 7495753
qtl_general number of animals used: 15-20 males 7495753
qtl_general software package used: one-way ANOVA 7495753
qtl_general spans 4.18 Mbp 7495753
qtl_general incorporates 2,753 variants 7495753