Bp369 QTL Report (Rattus norvegicus) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
QTL Registration

QTL: Bp369 (Blood pressure QTL 369) Rattus norvegicus

Symbol: Bp369
Name: Blood pressure QTL 369
RGD ID: 7488963
Previously known as: C17QTL1
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: mean arterial blood pressure   (CMO:0000009)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21759,005,649 - 77,910,000RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01765,497,359 - 82,019,219RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01767,248,685 - 83,762,100RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41769,576,957 - 89,078,870RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.LEW-(D17Chm131-D17Chm93)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
Hypotension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
2. Genetics of systolic and diastolic heart failure. Deng AY J Hypertens. 2015 Jan;33(1):3-13. doi: 10.1097/HJH.0000000000000400.
Related QTLs

Related QTL Description Reference
Bp370 interacts with RGD:7421500
Bp310 interacts with RGD:7421500


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
619776Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3176698362967064702Rat
61313Pterphosphotriesterase related177605838876119633Rat
61802Gdi2GDP dissociation inhibitor 2176664961666676299Rat
62389Klf6KLF transcription factor 6176453945664548451Rat
61893Pfkpphosphofructokinase, platelet176372974363794026Rat
2343Chrm3cholinergic receptor, muscarinic 3176000513760467250Rat
68347Celf2CUGBP, Elav-like family member 2177090446271729072Rat
620317Phyhphytanoyl-CoA 2-hydroxylase177332946173346359Rat
621634Itga8integrin subunit alpha 8177530400475501510Rat
620968Prkcqprotein kinase C, theta176724639467379049Rat
628708Zp4zona pellucida glycoprotein 4175900564959012202Rat
620011Atp5f1cATP synthase F1 subunit gamma176842392768446169Rat
619766Cdc123cell division cycle 123177245927072503316Rat
620783Gtpbp4GTP binding protein 4176130803361328184Rat
621115Olaholeoyl-ACP hydrolase177487765174902517Rat
628886Optnoptineurin177320957273260251Rat
708550Prpf18pre-mRNA processing factor 18177363056073661210Rat
68355Cubncubilin177638504676593133Rat
67385Cacnb2calcium voltage-gated channel auxiliary subunit beta 2177756463077910000Rat
708361Akr1c14aldo-keto reductase family 1, member C14176615628666173277Rat
2895Il2rainterleukin 2 receptor subunit alpha176684997466898665Rat
621835Idi1isopentenyl-diphosphate delta isomerase 1176162959261637357Rat
621250Gata3GATA binding protein 3176864376068666000Rat
708428Akr1c3aldo-keto reductase family 1, member C3176611097066127867Rat
708574Dclre1cDNA cross-link repair 1C177477582874810089Rat
1305149Il15rainterleukin 15 receptor subunit alpha176680230066831973Rat
1307514Akr1c15aldo-keto reductase family 1, member C15176618149366208090Rat
1306292Trdmt1tRNA aspartic acid methyltransferase 1177660196676646104Rat
1307600Cdnfcerebral dopamine neurotrophic factor177471456474728639Rat
1305027Sfmbt2Scm-like with four mbt domains 2176793429668128905Rat
1305898Bend7BEN domain containing 7177348321273566221Rat
1306298Fbh1F-box DNA helicase 1176674950666787590Rat
621646Vimvimentin177666870176677186Rat
1305034Net1neuroepithelial cell transforming 1176634125166370445Rat
1359406Akr1c12aldo-keto reductase family 1, member C12176604537666061496Rat
1311330Mcm10minichromosome maintenance 10 replication initiation factor177326378873288346Rat
1310713Larp4bLa ribonucleoprotein 4B176113866361217423Rat
1310998Pitrm1pitrilysin metallopeptidase 1176379567063827317Rat
1308232Akr1c13aldo-keto reductase family 1, member C13176596418665997598Rat
1303175Nmt2N-myristoyltransferase 2177491783374964788Rat
1311786Usp6nlUSP6 N-terminal like177182843371956878Rat
1309050Frmd4aFERM domain containing 4A177366778774258487Rat
1305499Calml3calmodulin-like 3176641984466423083Rat
1309305Slc39a12solute carrier family 39 member 12177735376177440384Rat
1306969Suv39h2SUV39H2 histone lysine methyltransferase177475629074775332Rat
1308092Dhtkd1dehydrogenase E1 and transketolase domain containing 1177235520172406725Rat
1309178Upf2UPF2, regulator of nonsense mediated mRNA decay177222457572335896Rat
1309353Mrc1mannose receptor, C type 1177724918777330857Rat
1306189Wdr37WD repeat domain 37176163725861703677Rat
1305948Sec61a2SEC61 translocon subunit alpha 2177240757472445630Rat
1309599Akr1e2aldo-keto reductase family 1, member E2176573590965750441Rat
1309605Mindy3MINDY lysine 48 deubiquitinase 3177554528675623884Rat
1311405Ankrd16ankyrin repeat domain 16176673532566748533Rat
1305289Tubal3tubulin, alpha-like 3176632373366332423Rat
1308977Ucmaupper zone of growth plate and cartilage matrix associated177329397773303709Rat
1310047Calml5calmodulin-like 5176639443366395352Rat
1307474Rpp38ribonuclease P/MRP subunit p38177491406674917742Rat
1310387Asb13ankyrin repeat and SOCS box-containing 13176656465366583365Rat
1306847Akr1c1aldo-keto reductase family 1, member C1176581047465837385Rat
1311208Rbm17RNA binding motif protein 17176693714066954034Rat
1564999RGD1564999similar to isopentenyl-diphosphate delta isomerase 2176151813861535484Rat
1562954Akr1c19aldo-keto reductase family 1, member C19176600135866027226Rat
1564347RGD1564347similar to isopentenyl diphosphate delta-isomerase type 2176137285361386459Rat
1561482Fam107bfamily with sequence similarity 107, member B177447860874685027Rat
1564456Tasor2transcription activation suppressor family member 2176658355466650127Rat
1564088Rpl29-ps3ribosomal protein L29, pseudogene 3176655246866553027Rat
1311841Akr1c2aldo-keto reductase family 1, member C2176575977865808013Rat
1559604Akr1c12l1aldo-keto reductase family 1, member C12-like 1176593783465948344Rat
1564164Acbd7acyl-CoA binding domain containing 7177490393674909977Rat
1564865AKR1C3l1aldo-keto reductase family 1 member C3-like 1176584758065881488Rat
1559783Idi2isopentenyl-diphosphate delta isomerase 2176133138561334987Rat
1559473Ccdc3coiled-coil domain containing 3177303189173135173Rat
1311182Sephs1selenophosphate synthetase 1177335443573382803Rat
1303161St8sia6ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6177674075576884178Rat
1303252Zmynd11zinc finger, MYND-type containing 11176054266960631913Rat
1303296Hspa14heat shock protein family A (Hsp70) member 14177472894574749727Rat
621519Adarb2adenosine deaminase RNA specific B2176175043762300984Rat
1565426Itih2inter-alpha-trypsin inhibitor heavy chain 2176837557468411849Rat
1586830Proser2proline and serine rich 2177215196172187524Rat
1564499Stamsignal transducing adaptor molecule177712023577166173Rat
1583655Meig1meiosis/spermiogenesis associated 1177481079174828433Rat
1560155Dip2cdisco-interacting protein 2 homolog C176064734661032467Rat
1562213Ucn3urocortin 3176630974866315996Rat
1582824Nip7-ps15nucleolar pre-rRNA processing protein NIP7, pseudogene 15176652539566526387Rat
1359284Nudt5nudix hydrolase 5177243569072459008Rat
1564416Hnrnpa1-ps26heterogeneous nuclear ribonucleoprotein A1, pseudogene 26176744541467446386Rat
1560691Camk1dcalcium/calmodulin-dependent protein kinase ID177258189972982704Rat
1589973Nsa2-ps11NSA2 ribosome biogenesis factor, pseudogene 11175962502059625946Rat
1589147Echdc3enoyl CoA hydratase domain containing 3177207069772093519Rat
1590637Tmem236transmembrane protein 236177718091977241258Rat
1589704Vdac1-ps6voltage-dependent anion channel 1, pseudogene 6176595464865959462Rat
1589705Smarce1-ps3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 3176408583764087092Rat
1589706Zzz3-ps1zinc finger, ZZ-type containing 3, pseudogene 1176387960163881399Rat
1589707Mcm7-ps1minichromosome maintenance complex component 7, pseudogene 1176366263563666781Rat
1589708Eef1g-ps11eukaryotic translation elongation factor 1 gamma, pseudogene 11176149758161498918Rat
1585155Moap1-ps1modulator of apoptosis 1, pseudogene 1176338020763381740Rat
1595454Rpl34-ps1ribosomal protein L34, pseudogene 1177487470674875132Rat
1596107KinKin17 DNA and RNA binding protein176841348368431392Rat
1594172Fam171a1family with sequence similarity 171, member A1177502458275148348Rat
1595507Hacd13-hydroxyacyl-CoA dehydratase 1177708150877106114Rat
1591781Rsu1Ras suppressor protein 1177612877476377515Rat
1591795C1ql3complement C1q like 3177611934476129170Rat
1591485Itih5inter-alpha-trypsin inhibitor heavy chain 5176824811568352216Rat
1598362LOC291276similar to isopentenyl diphosphate delta-isomerase type 2176154933561553178Rat
1595871Hspa8-ps5heat shock protein family A (Hsp70) member 8, pseudogene 5176409395964095858Rat
1642516Mt1-ps3metallothionein 1, pseudogene 3177478665274787040Rat
2319552Npm1-ps16nucleophosmin 1, pseudogene 16177078474070785697Rat
2319016Snrpe-ps2small nuclear ribonucleoprotein polypeptide E, pseudogene 2177089991670900190Rat
2322079LOC100360477hypothetical protein LOC100360477176147703761483516Rat
2321902Fth1-ps3ferritin heavy chain 1, pseudogene 3176785430467855385Rat
2321948Prmt1-ps1protein arginine methyltransferase 1, pseudogene 1176762545467626376Rat
2325483Mir511microRNA 511177727941577279493Rat
4888560Mir466dmicroRNA 466d176800326768003359Rat
2324594Taf3TATA-box binding protein associated factor 3176845538968608367Rat
2325073LOC100359655elongin B-like176220896662209274Rat
6489760LOC100911936uncharacterized LOC100911936176156873761578142Rat
6486636Atp5f1c-ps4ATP synthase F1 subunit gamma, pseudogene 4176758833167588976Rat
6497110Atp5mg-ps7ATP synthase membrane subunit g, pseudogene 7176363638763636687Rat
7519062Psmc6-ps1proteasome 26S subunit, ATPase 6, pseudogene 1176693180566937314Rat
7525245LOC102550536uncharacterized LOC102550536177658271976584183Rat
7541008LOC102551575isopentenyl-diphosphate delta-isomerase 2-like176150429461507015Rat
7541609LOC102546431uncharacterized LOC102546431176844292268457029Rat
7532113LOC102552793uncharacterized LOC102552793176742484467433157Rat
7646455LOC102552293uncharacterized LOC102552293176194057461982314Rat
7560065LOC102554589uncharacterized LOC102554589176489554064905757Rat
7640129Msantd7Myb/SANT DNA binding domain containing 7177472892774735527Rat
7656762LOC102547255uncharacterized LOC102547255177129575871309918Rat
7610313LOC102548033uncharacterized LOC102548033175933309059337521Rat
7617990LOC102552003uncharacterized LOC102552003176138493861387088Rat
7578249LOC102552867uncharacterized LOC102552867176768083067715001Rat
7751577LOC102546763uncharacterized LOC102546763176926251069321716Rat
7693725LOC102551026uncharacterized LOC102551026177252156572528731Rat
7723752LOC102554651uncharacterized LOC102554651177425872074261283Rat
7686967LOC102554523uncharacterized LOC102554523176483146264865907Rat
7740538LOC102550988isopentenyl-diphosphate delta-isomerase 2-like176145192061457799Rat
7666974LOC102551092uncharacterized LOC102551092177255979372562834Rat
7745365LOC102546657uncharacterized LOC102546657176895481068996252Rat
7746419LOC102555562uncharacterized LOC102555562177600056976003218Rat
7727712LOC102548534uncharacterized LOC102548534177586838275954711Rat
7749403LOC102548683uncharacterized LOC102548683176052111760528513Rat
9187604LOC103694135uncharacterized LOC103694135177552647575557758Rat
9206913LOC103694128small EDRK-rich factor 2 pseudogene177198121171981386Rat
9084032LOC103694151cytochrome c oxidase subunit 6B1 pseudogene177235414272355238Rat
9352023Idi2-ps1isopentenyl-diphosphate delta isomerase 2, pseudogene 1176142035761423924Rat
9378476LOC103690178nucleolar GTP-binding protein 1-like176140456161417990Rat
9362362LOC10369411660S ribosomal protein L22 pseudogene176108489261085261Rat
9474191LOC103694125uncharacterized LOC103694125176639104866393245Rat
9410960LOC103694152cyclin-dependent kinases regulatory subunit 2 pseudogene177357977273598021Rat
9685628Mir466cmicroRNA 466c176801786468017942Rat
11470481LOC108348621uncharacterized LOC108348621176070470960733102Rat
11471276LOC108348589uncharacterized LOC108348589177296402572998728Rat
11474069LOC108348592uncharacterized LOC108348592177458147374586792Rat
11369392LOC108348618uncharacterized LOC108348618177604398076055239Rat
11439047LOC108348486uncharacterized LOC108348486176715064967154089Rat
11394977LOC108348617protein transport protein Sec61 subunit gamma pseudogene177563844975638655Rat
11406958LOC108348582uncharacterized LOC108348582176401660964037489Rat
11389928LOC108348587uncharacterized LOC108348587177174963471753741Rat
11401537LOC108348616uncharacterized LOC108348616176571556665723420Rat
11478102Fbxl14-ps1F-box and leucine-rich repeat protein 14, pseudogene 1177365727373659619Rat
11502719LOC108348590uncharacterized LOC108348590177315579173158095Rat
11485055LOC108348614uncharacterized LOC108348614176329355663296453Rat
11517690LOC108348487nuclear cap-binding protein subunit 2 pseudogene176761583867621169Rat
14398573Mir466b-2microRNA mir-466b-2176803272868032809Rat
14398587Mir466b-1microRNA mir-466b-1176803575868035843Rat
41380062LOC120097894uncharacterized LOC120097894177397490173981948Rat
41205386LOC120098030U4 spliceosomal RNA176990167369901783Rat
41360715LOC120097741uncharacterized LOC120097741176768061267766669Rat
41387287LOC120098047U6 spliceosomal RNA176700865167008754Rat
41116272LOC120098055U6 spliceosomal RNA177095262870952728Rat
41145682LOC120097880uncharacterized LOC120097880177460550974623485Rat
41260975LOC120097910uncharacterized LOC120097910176815475868158084Rat
41363710LOC120098005small nucleolar RNA SNORA17176467024664670368Rat
41389710LOC120097878uncharacterized LOC120097878177483554374849584Rat
41096094LOC120097900uncharacterized LOC120097900176996062769985753Rat
41189467LOC120097896uncharacterized LOC120097896177407919274091043Rat
41264459LOC120097778uncharacterized LOC120097778176897314669007426Rat
41155374LOC120097737uncharacterized LOC120097737176620708866215750Rat
41155484Hspe1-ps1heat shock protein family E (Hsp10) member 1, pseudogene 1176369272063713407Rat
41156892LOC120097906uncharacterized LOC120097906175913071959138035Rat
41193472LOC120097862uncharacterized LOC120097862176672547766727913Rat
41218517Slc23a2-ps1solute carrier family 23 member 2, pseudogene 1176607559066082748Rat
41184525LOC120097849uncharacterized LOC120097849176835628368360010Rat
41219403Adi1-ps1acireductone dioxygenase 1, pseudogene 1176098927360989828Rat
41373662LOC120097897uncharacterized LOC120097897177412528774128014Rat
41105207LOC120097756uncharacterized LOC120097756176714395667148274Rat
41186790LOC120097832uncharacterized LOC120097832176650409166507987Rat
41401159Arpc5l-ps2actin related protein 2/3 complex, subunit 5-like, pseudogene 2176683672066837695Rat
41200047LOC120097925uncharacterized LOC120097925176494795064970825Rat
41353002Trnaa-cgc5transfer RNA alanine (anticodon CGC) 5177782179777821869Rat
41403456LOC120097922uncharacterized LOC120097922177092649670934280Rat
41202623LOC120097970U7 small nuclear RNA177568080275680865Rat
40997098LOC120097918uncharacterized LOC120097918176941217069418345Rat
41015985Idi2-ps2isopentenyl-diphosphate delta isomerase 2, pseudogene 2176160125461608261Rat
41339945LOC120097764isopentenyl-diphosphate delta-isomerase 2-like176133862261349795Rat
40950915LOC120097951uncharacterized LOC120097951176823747168242527Rat
41341161Srsf3-ps9serine and arginine rich splicing factor 3, pseudogene 9176575656765759644Rat
40953259LOC120097958uncharacterized LOC120097958177539144475396471Rat
41014789LOC120098050U6 spliceosomal RNA177191544671915547Rat
40957286LOC120097881uncharacterized LOC120097881177474429974747340Rat
40981689LOC120098027U4 spliceosomal RNA177495361474953754Rat
40959177Eef1g-ps8eukaryotic translation elongation factor 1 gamma, pseudogene 8176155698761562152Rat
40936831LOC120097916uncharacterized LOC120097916177334795573356920Rat
40940378LOC120097971U7 small nuclear RNA177551964375519707Rat
40967226LOC120097887uncharacterized LOC120097887176367751663690603Rat
41242720LOC120097870uncharacterized LOC120097870176124753661263382Rat
41243501LOC120097813uncharacterized LOC120097813175933758259355633Rat
41048340LOC120097919uncharacterized LOC120097919176555315765559311Rat
41049176LOC120097994small nucleolar RNA SNORA17176968051769680648Rat
41312831LOC120097798uncharacterized LOC120097798176668645566688084Rat
41134540LOC120097974small nucleolar RNA SNORA68176753442767534557Rat
41143387LOC120098018U2 spliceosomal RNA177774839777748583Rat
41220445LOC120097984small nucleolar RNA SNORA48176469517764695319Rat
41057970LOC120097860uncharacterized LOC120097860176557138565573214Rat
41298822LOC120097902uncharacterized LOC120097902176671331566716474Rat
41299169LOC120097893uncharacterized LOC120097893177372224873725978Rat
41060414LOC120097950uncharacterized LOC120097950176826388568273069Rat
41224909LOC120097843uncharacterized LOC120097843176863732268641249Rat
41303092LOC120097988small nucleolar RNA SNORA17176842872368428851Rat
41239690LOC120097879uncharacterized LOC120097879177466319074672471Rat
41044963LOC120098044U6 spliceosomal RNA176557634565576451Rat
41240389LOC120097895uncharacterized LOC120097895177371619473736993Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10348D17Mit4215176046341260463643Ratregion
10349D17Arb7221176046340560463642Ratregion
10350D17Wox12121176046350060463637Ratregion
10351D17Wox13134176046348360463633Ratregion
10490D5Uwm5173177589418175894750Ratregion
34391D17Mgh9148176811706768117215Ratregion
33707D17Mit5287177085256570852846Ratregion
36211D17Rat34172176227078862270949Ratregion
36315D17Rat41175176883571268835887Ratregion
37234D17Rat97234176210933362109574Ratregion
37404D17Rat82199176877890768779104Ratregion
35258D17Rat36188176364000963640182Ratregion
35274D17Rat45126177100332571003451Ratregion
35473D17Rat58143176959919769599340Ratregion
36844D17Rat48168177750219477502357Ratregion
37068D17Rat42140177121497771215120Ratregion
37762D17Rat170170175949767959497857Ratregion
37926D17Rat62143177242009472420215Ratregion
36392D17Mgh12177604425876044398Ratregion
36526D17Rat46131177254020672540337Ratregion
36783D17Rat172126176759541267595534Ratregion
34989D17Rat39154176570358065703715Ratregion
35052D17Rat33126176011018860110323Ratregion
35136D17Rat37164176475909664759263Ratregion
35585D17Rat151166176078142660781592Ratregion
35687D17Rat47126177395087173951021Ratregion
35687D17Rat47126177395089573951021Ratregion
35707D17Rat43147177106086271061009Ratregion
35883D17Rat44141177015677770156904Ratregion
35893D17Rat38158176355506163555219Ratregion
39692D17Rat139133176880741568807548Ratregion
39786D17Rat129165176869929768699464Ratregion
37998D17Rat96205176704777767047980Ratregion
40114D17Rat122125176000088060000997Ratregion
40316D17Rat124128176117751661177650Ratregion
38894D17Rat60239177711288277113120Ratregion
39432D17Rat130210177048107670481278Ratregion
39488D17Rat127244176455464964554895Ratregion
39566D17Rat126246176419468864194936Ratregion
41510D17Rat128146176405521464055360Ratregion
42419D17Rat180249177145068271450924Ratregion
43101D17Rat152229176855090968551143Ratregion
43102D17Rat153228176961631469616542Ratregion
45482D17Got75218175996373459963952Ratregion
45484D17Got74195176001893760019130Ratregion
45487D17Hmgc2202176108840561088605Ratregion
45488D17Got80171176348992063490091Ratregion
45489D17Got124153176437868564378838Ratregion
45491D17Got87124176691767666917800Ratregion
45494D17Got82292176794876467949054Ratregion
45495D17Got88150176761546867615619Ratregion
45496D17Wox6152176881769968817853Ratregion
45497D17Got84218176769069667690914Ratregion
45498D17Got89221176838026868380486Ratregion
45499D17Wox21153176881769168817870Ratregion
45500D17Got91177177100332971003506Ratregion
45502D17Got92164177289639872896562Ratregion
45504D17Got94146177444277374442921Ratregion
45505D17Got93205177491345174913656Ratregion
45506D17Got96229177598330875983537Ratregion
45507D17Got95152177627942076279572Ratregion
45508D17Got100196177620105576201249Ratregion
45509D17Wox7185177784891177849094Ratregion
60162D17Got98107177597687575976982Ratregion
60163D17Got99174177777866877778842Ratregion
67819D17Uwm2264177236590772366191Ratregion
625788D17Got85145176748978267489927Ratregion
629582D17Got83209176683600366836209Ratregion
61300D17Mco3259175955501359555289Ratregion
67260D17Arb12297177790769977907996Ratregion
1556754D17Chm14199176878393768784138Ratregion
1556756D17Chm9196177177462171774817Ratregion
1556758D17Chm2221177097378470974005Ratregion
1631795D17Got216106176103579161035895Ratregion
1628173D17Got209176177058758770587763Ratregion
1628173D17Got209176177058758770588182Ratregion
1628173D17Got209176177058771070587763Ratregion
1635873D17Wox31196176617551566175711Ratregion
1637583D17Got22688176836697968367067Ratregion
1633898D17Got213169177096213170962300Ratregion
7192418VIM170177667280576673055Ratregion
7206732MARC_4455-4456:966894277:1115176370976963709885Ratregion
5038868RH127379220176667669266676912Ratregion
5039274RH127612211176379369263793903Ratregion
5036763AU049126171177712704277127213Ratregion
5028723D5S2467176177298252272982698Ratregion
5031508AU048093284176215714862157432Ratregion
5031510AU048087123177433692874337051Ratregion
5034073RH141259197177709555377095750Ratregion
5026162RH131151191177708170377081894Ratregion
5026168RH131175202177530411075304312Ratregion
5028769RH142262199176453980364540002Ratregion
5034482BF41563097176054527560545372Ratregion
5034484BF415683149177195763071957779Ratregion
5029107RH143550231177402080574021036Ratregion
5031906AU046752267176827789368278160Ratregion
5034754AI009647198176664861366648811Ratregion
5026788RH133530194177477348374773677Ratregion
5035158AW532891155177514501075145165Ratregion
5027119RH70526130175944187759442007Ratregion
5027213AI79031887177611889476118981Ratregion
5029791BE102654176176680861266808788Ratregion
5029987AI072301216177477703174777247Ratregion
5035272AI704007203177335728273357485Ratregion
5030213BG379597109177366790573668014Ratregion
5032961RH137116181177491788274918064Ratregion
5025108C86813234176453956564539798Ratregion
5030345BF402956144177151835671518500Ratregion
5030427BF397554157177260647472606631Ratregion
5033191RH137920240177493867174938910Ratregion
5025354RH127990192177491752974917721Ratregion
5025368RH128044190177661278076612970Ratregion
5030617BE113707158176656501366565171Ratregion
5030623BI301335218177511063975110857Ratregion
5033465RH138936137177172813271728269Ratregion
5033507RH139079145176837557368375718Ratregion
5028129D11Mit209115177189982371899938Ratregion
5033703RH139807218177256256572562783Ratregion
5054877RH143476127177759880177598928Ratregion
5053671RH142783108176064869960648807Ratregion
5056407RH144360167177112539771125564Ratregion
5053843RH142882118177635368876353806Ratregion
5056847RH144615181177776698477767165Ratregion
5057390AA893351152177612085176121003Ratregion
5057512AA819637209177172895171729161Ratregion
5055191RH143658209177612992976130138Ratregion
5055361RH143757157176615702466157181Ratregion
5054587RH143310236176163101761631258Ratregion
5059514BE097150166177770870277708868Ratregion
5057574BE095613153177169591771696070Ratregion
5054953RH143521205177612887276129082Ratregion
5058020BF386478158177716624277166400Ratregion
5056709RH144534289177418086174181150Ratregion
5058874BI278109189177230025172300440Ratregion
5058878BI278113177177368294773683124Ratregion
5059962BF388238162177151911371519275Ratregion
5049876RH133733199177767327577673474Ratregion
5049968RH133786201177243425272434453Ratregion
5050130RH133879218177243388472434102Ratregion
5053703RH142802124177613092376131047Ratregion
5049820RH133700185176667549866675683Ratregion
5051052RH134411220176724657967246799Ratregion
5054061RH143008120176685005766850177Ratregion
5050252RH133949206176898922568989431Ratregion
5051318AI25616181177332930873329389Ratregion
5051423AW214366123176762553267625655Ratregion
5053361RH142604161176133161861331779Ratregion
5053361RH142604161176133161861331779Ratregion
5040790RH128485184176454238964542573Ratregion
5044366RH130561208176162966161629869Ratregion
5044822RH130823211177182845471828665Ratregion
5041356RH128810194176637012266370316Ratregion
5044046RH130379215177183164271831857Ratregion
5044072RH130394219177366092673661145Ratregion
5044462RH130616214176642277466422988Ratregion
5044942RH130892198176881994968820147Ratregion
5044916RH130877218177218713472187352Ratregion
5045006RH130929182177477599774776179Ratregion
5045114RH130992183177240621372406396Ratregion
5048952RH133201184177303350873033692Ratregion
5048992RH133224204177233642672336832Ratregion
5045870RH131426188177335801073358198Ratregion
5047888RH132586192176866504468665236Ratregion
5047900RH132593201177328707473287275Ratregion
5047994RH132647216177303507073035286Ratregion
5049240RH133366183176678731066787493Ratregion
5046914RH132027200177328749073287690Ratregion
5042152RH129270203176113881661139019Ratregion
5047382RH132295204177661077276610976Ratregion
5048538RH132961187176170344061703620Ratregion
5048610RH133003209176788537467885713Ratregion
5048644RH133022204177389025273890456Ratregion
5049640RH133597189176379581663796005Ratregion
5039398RH127683215176063156860631783Ratregion
5043004RH129774213176714642867146641Ratregion
5043168RH129871194177332914973329343Ratregion
5039842RH127938189176575009965750288Ratregion
5042274RH129340185177790837977908564Ratregion
5043340RH129970182177554536875545550Ratregion
5041112RH128669163177217541272175575Ratregion
5040310RH128210187177638518976385376Ratregion
5042898RH129710218176860699968607217Ratregion
5043054RH129805153177209334072093493Ratregion
5074912RH138290129177493795474938083Ratregion
5073854RH137677170177502473975024909Ratregion
5075346RH138541150177666793376668083Ratregion
5075406RH138575153177784640077846553Ratregion
5072284RH136760143177325997073260113Ratregion
5072340RH136792228176860810368608331Ratregion
5075926RH138877152177241878772418939Ratregion
5076346RH139122143176873649568736638Ratregion
5072750RH137031213176132859461328807Ratregion
5072750RH137031213176132859461328807Ratregion
5072750RH137031213176141788961418102Ratregion
5072750RH137031213176141788961418102Ratregion
5076080RH138967152176064864860648800Ratregion
5075592RH138683166177448508574485251Ratregion
5077668RH139889198176163748061637678Ratregion
5075740RH138769212176695436666954578Ratregion
5076264RH139075168177172848371728651Ratregion
5077882RH140014197177371757473717771Ratregion
5076518RH139222135177329424473294379Ratregion
5077842RH139991196176860810368608299Ratregion
5077952RH140056192176103023461030426Ratregion
5078564RH140417219177116013771160356Ratregion
5080010RH141331183177366981973670002Ratregion
5079136RH140756175176594808965948264Ratregion
5079136RH140756175176599734465997519Ratregion
5070886RH134762188176639463566394823Ratregion
5080262RH141478150177716574077165890Ratregion
5073916RH137713132177171821571718347Ratregion
5071912RH135357181177268207972682260Ratregion
5074268RH137918182177284054172840723Ratregion
5074446RH138021203177790743377907636Ratregion
5071346RH135029193177790971777909910Ratregion
5073710RH137593155176175060561750759Ratregion
5072448RH136855214176825227968252493Ratregion
5061716BF40256699177265993272660031Ratregion
5064966BE108794160176656245166562611Ratregion
5066978AU048037162177157552471575688Ratregion
5067072AU047982163177290468372904846Ratregion
5067892AU047473258176894229368942771Ratregion
5067892AU047473258176894251768942771Ratregion
5068832AU046899269176157905261579322Ratregion
5068832AU046899269176157905261579322Ratregion
5069730AU046308122176272080462720926Ratregion
5061874AW533955177176598174665981926Ratregion
5061922BI294222117177284133972841456Ratregion
5062088BI294994156177325987373260029Ratregion
5062414BF397898176177328648673286662Ratregion
5063890BE120177168177546313375463301Ratregion
5064004BE120415151177136920671369357Ratregion
5062656BF403708220176210119262101412Ratregion
5064454BE108020152177118411371184265Ratregion
5065822BE109990175177790815777908332Ratregion
5065868AA964004186177611900476119191Ratregion
5060190BF400671119177151422571514345Ratregion
5061970BF397013122177605913676059258Ratregion
5065284BE121379151176573632165736472Ratregion
5060508BE110243151177413368774133838Ratregion
5060586BE098513150176165221361652363Ratregion
5063850BE120058195177276150872761703Ratregion
5065546BE109264227177250213072502831Ratregion
5065730BE109742154177716564377165797Ratregion
5062532BI288939132177348490373485035Ratregion
5064330BE114414191176841351868413709Ratregion
5064402BI302100160176619636666196526Ratregion
5061460BE105222189177717230277172491Ratregion
5084388AI233834243177611958976119832Ratregion
5086995BE106817172176658207166582243Ratregion
5086062AW529448166177757967277579838Ratregion
5086240BM386226187177606710776067294Ratregion
5087070BM387785215177322902673229241Ratregion
5086555BE114437173176908521669085389Ratregion
5086558BM385825157177258539972585554Ratregion
5082683BF416571213176182705361827266Ratregion
5082877BF390310209177170388471704093Ratregion
5089153AU048986107177474167774741716Ratregion
5089939AU049454268176099615560996421Ratregion
5083071BF390754200177151223771512437Ratregion
5089281AU049062188175979416959794357Ratregion
5090669AU049890293176437563064375921Ratregion
5088605AU048669185176743504567435230Ratregion
5089685AU049302280176140062661400896Ratregion
5083998AA894002207177328808573288292Ratregion
5084406AI40898296176167090961671005Ratregion
5084862AI008532182177151375871513940Ratregion
5080998RH141904210176639017766390387Ratregion
5085671AW535579181176863918268639363Ratregion
5081382AI385205182176695243966953772Ratregion
5084484AI013758154176793430967934463Ratregion
5086106AI233437160176822796468228124Ratregion
5086203BE111954215177480204074802255Ratregion
5086315BM387042158177658301876583828Ratregion
5083087BF390786156177242944372429599Ratregion
5083187BF390950154177368501073685164Ratregion
5086592BE114499170177333435673334526Ratregion
5086634BQ205792172176455217764552349Ratregion
5085713AA849380155176118296261183117Ratregion
5083936AA893268250177709116377091413Ratregion
5503174ksks283325177476681774767142Ratregion
5507549G06312246176063161260631858Ratregion
5503716SEPHS1_9288834177335712773357961Ratregion
5507709UniSTS:25682101176063174660631847Ratregion
5504308D10S1340E111176063174660631857Ratregion
5504338D11S3020208177399021473990422Ratregion
5504805Hrmt1l2212176762614767626358Ratregion
5505774UniSTS:4930721679176674681366748492Ratregion
5506334MARC_50801-50802:1130354928:1218177550049775500715Ratregion
5506833G46301184176368764763687831Ratregion
5507041fb22g09.x1919176685866666859585Ratregion
5507271fc41h02.x1817175992373059924675Ratregion
5507287fb54b04.x10176000564260006974Ratregion
5507287fb54b04.x10176000564260006996Ratregion
5502080MARC_31619-31620:1062167711:1172177667459876675170Ratregion
5500741G26357217176062989760630114Ratregion
5500793stSG625620867175930361859304485Ratregion
5503394VIM128177667281476673022Ratregion
5501365G15938233177790774577907978Ratregion
5501568RH3672477177335720673357283Ratregion
5502120MARC_5003-5004:996690032:1176176844133968442557Ratregion
5502385RH124704380177638514376385523Ratregion
5506907G47699239176249047262490711Ratregion
5502529RH125200126176454212064542245Ratregion
Position Markers

Flank 1: (Zp4)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21759,005,649 - 59,012,202 (-)NCBI
mRatBN7.2 Ensembl1759,005,649 - 59,012,202 (-)Ensembl
UTH_Rnor_SHR_Utx1762,200,994 - 62,207,550 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01766,204,050 - 66,210,606 (-)NCBI
UTH_Rnor_WKY_Bbb_1.01760,358,390 - 60,364,946 (-)NCBI
Rnor_6.01765,497,359 - 65,503,912 (+)NCBI
Rnor_6.0 Ensembl1765,497,359 - 65,503,912 (+)Ensembl
Rnor_5.01767,248,685 - 67,255,238 (+)NCBI
RGSC_v3.41769,576,957 - 69,583,510 (-)NCBI
RGSC_v3.11769,587,789 - 69,594,343 (-)NCBI
Celera1761,538,443 - 61,544,996 (+)NCBI
Cytogenetic Map17q12.1NCBI
Flank 2: (Cacnb2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,630 - 77,910,000 (+)NCBI
mRatBN7.2 Ensembl1777,564,460 - 77,909,106 (+)Ensembl
UTH_Rnor_SHR_Utx1781,014,900 - 81,360,395 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01784,850,313 - 85,195,829 (+)NCBI
UTH_Rnor_WKY_Bbb_1.01778,898,224 - 79,243,725 (+)NCBI
Rnor_6.01781,673,862 - 82,019,219 (+)NCBI
Rnor_6.0 Ensembl1781,798,756 - 82,017,682 (+)Ensembl
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
RGSC_v3.41788,832,905 - 89,078,870 (+)NCBI
RGSC_v3.11788,864,078 - 89,089,703 (+)NCBI
Celera1776,999,835 - 77,240,592 (+)NCBI
Cytogenetic Map17q12.3NCBI


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)175402992960463637Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)177100332581153923Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general measurement method: selected males were weaned at 21 days of age then fed 2% NaCl diet starting from 35 days of age; telemetric probes were implanted at 56 days of age and blood pressure recorded after 10 days 7421500
qtl_general number of animals used: 12 gender: male 7421500
qtl_general software package used: ANOVA followed by Dunnett test 7421500